|N-((2,3-二氢苯并[b][1,4]二恶-2-基)甲基)甲基)-2-(2,6-二甲氧基苯氧基)乙胺盐酸盐|CsnPharm

CAS No.: 2170-58-3

Synonyms: 2-[(2,6-Dimethoxyphenoxyethyl)aminomethyl]-1,4-benzodioxane hydrochloride;WB-4101;WB 4101 hydrochloride

WB 4101 hydrochloride is a selective antagonist of α1A-adrenergic receptor.

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400-920-2911

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描述WB 4101 hydrochloride, a recently described alpha-adrenoceptor antagonist, in blocking an excitatory and two inhibitory responses to alpha-receptor activation was studied. One of the inhibitory responses was the reduction by the selective alpha-agonist amidephrine of carbachol contractures of isolated guinea-pig taenia caeci. WB 4101 was, however, several hundred times less active in antagonising the inhibitory effect of clonidine on the twitch response of the vas deferens to field stimulation. The twitch was increased by low concentrations of amidephrine, and by relatively high concentrations of WB 4101^[1]. The alpha 1- and alpha 2-adrenoceptor blocking activity of WB-4101 resides predominantly in the (S)-enantiomer and that both enantiomers of WB-4101 are selective alpha 1-adrenoceptor antagonists in vivo^[2]. WB 4101 was approximately 97 times more potent at antagonizing the vasopressor responses produced by the selective alpha 1-adrenoceptor agonist phenylephrine, than those produced by the selective alpha 2-adrenoceptor agonist M-7. A dose of WB 4101 (3 mg/kg) that caused extensive blockade of vascular alpha 1-adrenoceptors, but little or no blockade of vascular alpha 2-adrenoceptors, exerted no significant blockade of the presynaptic alpha 2-adrenoceptors in the rat heart^[3].
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技术信息

CAS号	2170-58-3	储存条件	粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C19H24ClNO5	运输	蓝冰
分子量	381.85	别名	2-[(2,6-Dimethoxyphenoxyethyl)aminomethyl]-1,4-benzodioxane hydrochloride;WB-4101;WB 4101 hydrochloride;WB 4101 HCl

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