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CAS No.: 1684-40-8

盐酸他克林 Catalog No. CSN12024

Synonyms: Tacrine (hydrochloride);C.I. 970;Hydroaminacrine

Tacrine HCl is a parasympathomimetic reversible cholinesterase inhibitor.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Tacrine (Hydrochloride) is a potent inhibitor of cholinesterases and has ChE inhibitory activity and additional biological activity such as monoamine oxidase (MAO) inhibition and ion channel modulating ability. The hybrid compound containing the tryptoline moiety linked with a 7 carbon spacer to tacrine displayed the best AChE and BuChE inhibitory activity (IC50 = 17.37 and 3.16 nM)^[3]. Pretreatment with tacrine can decrease cocaine-motivated behavior measured by self-administration or reinstatement, but not conditioned-place preference^[4].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02292238	Alzheimer's Disease	Phase 2	Recruiting	November 2019	United States, New York ... more >> Burke Recruiting White Plains, New York, United States, 10605 Contact: Liz Magier, MPA 914-368-3159 burkegrants@med.cornell.edu Collapse <<
NCT02821975	Depression in Remission ... more >> Cognitive Computer Training Returning to Work Collapse <<	Not Applicable	Unknown	October 2017	Denmark ... more >> Research Unit of Psychiatry, Psychiatric Unit Odense - University function Recruiting Odense C, Region of southern Denmark, Denmark, 5000 Contact: Anja F Elliott, BACH.MED. +4560795724 anjaelliott@hotmail.com Collapse <<
NCT01406522	Cocaine Dependence	Phase 2	Withdrawn(One of the study med... more >>ications, tacrine, is no longer clinically available) Collapse <<	November 2013	United States, Missouri ... more >> Kansas City VA Medical Center Kansas City, Missouri, United States, 64128 Collapse <<

更多
参考文献

[1] Snape MF, Misra A, et al. A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066. Neuropharmacology. 1999 Jan;38(1):181-93.
[2] Freeman SE, Dawson RM. Tacrine: a pharmacological review. Prog Neurobiol. 1991;36(4):257-77.
[3] Teponnou GAK, Joubert J, Malan SF. Tacrine, Trolox and Tryptoline as Lead Compounds for the Design and Synthesis of Multi-target Agents for Alzheimer's Disease Therapy. Open Med Chem J. 2017 Jan 31;11:24-37. doi: 10.2174/1874104501711010024. PMID: 28567126; PMCID: PMC5418947.
[4] Grasing K, Yang Y, He S. Enduring effects of tacrine on cocaine-reinforced behavior: Analysis by conditioned-place preference, temporal separation from drug reward, and reinstatement. Pharmacol Res. 2015 Jul;97:40-7. doi: 10.1016/j.phrs.2015.04.003. Epub 2015 Apr 16. PMID: 25890194; PMCID: PMC4465028.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.2603 mL
- 21.3016 mL
- 42.6031 mL
- 5 mM
- 0.8521 mL
- 4.2603 mL
- 8.5206 mL
- 10 mM
- 0.4260 mL
- 2.1302 mL
- 4.2603 mL

技术信息

CAS号

1684-40-8

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C13H15ClN2

运输

蓝冰

分子量

234.72

别名

Tacrine (hydrochloride);C.I. 970;Hydroaminacrine;NSC-72108;盐酸他克林

溶解度

DMSO	46.0 mg/mL (196.0 mM)
Water	45.0 mg/mL (191.7 mM)
Ethanol	45.0 mg/mL (191.7 mM)

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02292238	Alzheimer's Disease	Phase 2	Recruiting	November 2019	United States, New York ... more >> Burke Recruiting White Plains, New York, United States, 10605 Contact: Liz Magier, MPA 914-368-3159 burkegrants@med.cornell.edu Collapse <<
NCT02821975	Depression in Remission ... more >> Cognitive Computer Training Returning to Work Collapse <<	Not Applicable	Unknown	October 2017	Denmark ... more >> Research Unit of Psychiatry, Psychiatric Unit Odense - University function Recruiting Odense C, Region of southern Denmark, Denmark, 5000 Contact: Anja F Elliott, BACH.MED. +4560795724 anjaelliott@hotmail.com Collapse <<
NCT01406522	Cocaine Dependence	Phase 2	Withdrawn(One of the study med... more >>ications, tacrine, is no longer clinically available) Collapse <<	November 2013	United States, Missouri ... more >> Kansas City VA Medical Center Kansas City, Missouri, United States, 64128 Collapse <<
NCT01906957	Metabolic Syndrome ... more >> Coronary Heart Disease Chronic Heart Failure Collapse <<	Not Applicable	Unknown	October 2018	Canada, Quebec ... more >> Cardiovascular Prevention and Rehabilitation Centre, Montreal Heart Institute Recruiting Montreal, Quebec, Canada, H1T 1N6 Contact: Julie Lalongé +1-514-374-1480 ext 259 julie.lalonge@icm-mhi.org Principal Investigator: Mathieu Gayda, Ph.D Cardiovascular Prevention and Rehabilitation Centre (EPIC), Montreal Heart Institute Not yet recruiting Montreal, Quebec, Canada, H1T1N6 Contact: Julie Lalongé, RT 514-374-1480 ext 259 julie.lalonge@icm-mhi.org Principal Investigator: Mathieu Gayda, Ph.D Collapse <<
NCT03018561	Metabolic Syndrome ... more >> Coronary Artery Disease Heart Failure Collapse <<	Not Applicable	Completed	-	-
NCT01906957	Metabolic Syndrome ... more >> Coronary Heart Disease Chronic Heart Failure Collapse <<	Not Applicable	Unknown	October 2018	Canada, Quebec ... more >> Cardiovascular Prevention and Rehabilitation Centre, Montreal Heart Institute Recruiting Montreal, Quebec, Canada, H1T 1N6 Contact: Julie Lalongé +1-514-374-1480 ext 259 julie.lalonge@icm-mhi.org Principal Investigator: Mathieu Gayda, Ph.D Cardiovascular Prevention and Rehabilitation Centre (EPIC), Montreal Heart Institute Not yet recruiting Montreal, Quebec, Canada, H1T1N6 Contact: Julie Lalongé, RT 514-374-1480 ext 259 julie.lalonge@icm-mhi.org Principal Investigator: Mathieu Gayda, Ph.D Collapse <<
NCT03018561	Metabolic Syndrome ... more >> Coronary Artery Disease Heart Failure Collapse <<	Not Applicable	Completed	-	-
NCT01406522	Cocaine Dependence	Phase 2	Withdrawn(One of the study med... more >>ications, tacrine, is no longer clinically available) Collapse <<	November 2013	United States, Missouri ... more >> Kansas City VA Medical Center Kansas City, Missouri, United States, 64128 Collapse <<
NCT02821975	Depression in Remission ... more >> Cognitive Computer Training Returning to Work Collapse <<	Not Applicable	Unknown	October 2017	Denmark ... more >> Research Unit of Psychiatry, Psychiatric Unit Odense - University function Recruiting Odense C, Region of southern Denmark, Denmark, 5000 Contact: Anja F Elliott, BACH.MED. +4560795724 anjaelliott@hotmail.com Collapse <<
NCT02292238	Alzheimer's Disease	Phase 2	Recruiting	November 2019	United States, New York ... more >> Burke Recruiting White Plains, New York, United States, 10605 Contact: Liz Magier, MPA 914-368-3159 burkegrants@med.cornell.edu Collapse <<

盐酸他克林 Catalog No. CSN12024

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