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CAS No.: 4773-96-0

芒果苷 Catalog No. CSN16363

Synonyms: 芒果苷

Mangiferin is the predominant constituent of extracts of the mango plant Mangifera Indica L. with potential antidiabetic activity.

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技术信息

生物活性

描述Mangiferin is a xanthone present in significant levels in higher plants. Methanolic mangiferin extracts are potent antioxidants (EC50:5.8 ± 0.96 μg/ml). The administration of mangiferin (1, 10, 100 μg/ml) significantly increased the resistance of erythrocyte cells to hydrogen peroxide-induced reactive oxygen species (ROS). Mangiferin against glycated protein/chelate iron-induced toxicity in human umbilical vein endothelial cells^[3]. Moreover, mangiferin may inhibit osteoclastic bone resorption by suppressing differentiation of osteoclasts and promoting expression of ERβ mRNA in mouse bone marrow macrophage cells^[4].
参考文献

[1] Song J, Li J, et al. Mangiferin inhibits endoplasmic reticulum stress-associated thioredoxin-interacting protein/NLRP3 inflammasome activation with regulation of AMPK in endothelial cells. Metabolism. 2015 Mar;64(3):428-37.
[2] Miura T, Ichiki H, et al. Antidiabetic activity of a xanthone compound, mangiferin. Phytomedicine. 2001 Mar;8(2):85-7.
[3] Imran M, Arshad MS, Butt MS, Kwon JH, Arshad MU, Sultan MT. Mangiferin: a natural miracle bioactive compound against lifestyle related disorders. Lipids Health Dis. 2017 May 2;16(1):84. doi: 10.1186/s12944-017-0449-y. PMID: 28464819; PMCID: PMC5414237.
[4] Sekiguchi Y, Mano H, Nakatani S, Shimizu J, Kataoka A, Ogura K, Kimira Y, Ebata M, Wada M. Mangiferin positively regulates osteoblast differentiation and suppresses osteoclast differentiation. Mol Med Rep. 2017 Aug;16(2):1328-1332. doi: 10.3892/mmr.2017.6752. Epub 2017 Jun 12. PMID: 28627701; PMCID: PMC5562065.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3678 mL
- 11.8388 mL
- 23.6776 mL
- 5 mM
- 0.4736 mL
- 2.3678 mL
- 4.7355 mL
- 10 mM
- 0.2368 mL
- 1.1839 mL
- 2.3678 mL

技术信息

CAS号

4773-96-0

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C19H18O11

运输

蓝冰

分子量

422.34

别名

芒果苷

溶解度

DMSO	84.0 mg/mL (198.9 mM)

动物实验配方

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