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CAS No.: 481-72-1

芦荟大黄素 Catalog No. CSN17350

Synonyms: NSC 38628;Rhabarberone;3-Hydroxymethylchrysazine

Aloe-emodin, a natural product isolated and purified from the root of Rheum palmatum L. with a specific in vitro and in vivo anti-neuroectodermal tumor activity, reduces the toxicity and ROS induced by both monomeric and oligomeric Aβ species, appears to have some protective effect not only against hepatocyte death but also on the inflammatory response subsequent to lipid peroxidation and has a strong non-carcinogenic stimulant-laxative action when applied to the skin, although it may increase the carcinogenicity of some kind of radiation. Aloe-Emodine dose-dependently inhibited cleavage activity of the 3CLpro with IC50 value of 366μM in the cell-based assay.

规格	价格	促销价格	库存	数量

400-920-2911

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实验方案

技术信息

生物活性

描述Aloe-emodin, a natural product isolated and purified from the root of Rheum palmatum L. with a specific in vitro and in vivo anti-neuroectodermal tumor activity, reduces the toxicity and ROS induced by both monomeric and oligomeric Aβ species, appears to have some protective effect not only against hepatocyte death but also on the inflammatory response subsequent to lipid peroxidation and has a strong non-carcinogenic stimulant-laxative action when applied to the skin, although it may increase the carcinogenicity of some kind of radiation.
细胞研究

Cell Data

Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
A2780 cells	-	Cytotoxicity assay	-	Cytotoxicity against human A2780 cells, IC50=26 μM	24326280
HCT116 cells	-	Cytotoxicity assay	24 h	Cytotoxicity against MDR1 Pgp under-expressing human HCT116 cells after 24 hrs by MTT assay, IC50=8.7 μM	17949858
HepG2 cells	-	Cytotoxicity assay	24 h	Cytotoxicity against MDR1 Pgp overexpressing human HepG2 cells after 24 hrs by MTT assay, IC50=10 μM	17949858

参考文献

[1] Ho SL, Poon CY, et al. Inhibition of β-amyloid Aggregation By Albiflorin, Aloeemodin And Neohesperidin And Their Neuroprotective Effect On Primary Hippocampal Cells Against β-amyloid Induced Toxicity. Curr Alzheimer Res. 2015;12(5):424-33.
[2] Heidemann A, Volkner W, Mengs U. Genotoxicity of aloeemodin in vitro and in vivo. Mutat Res. 1996 Mar 1;367(3):123-33.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.7005 mL
- 18.5023 mL
- 37.0046 mL
- 5 mM
- 0.7401 mL
- 3.7005 mL
- 7.4009 mL
- 10 mM
- 0.3700 mL
- 1.8502 mL
- 3.7005 mL

技术信息

CAS号

481-72-1

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H10O5

运输

蓝冰

分子量

270.24

别名

NSC 38628;Rhabarberone;3-Hydroxymethylchrysazine;芦荟大黄素

溶解度

DMSO	73.0 mg/mL (270.1 mM)
Water	insoluble

动物实验配方

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