|1-((2R,3R,4R,5R)-3-氟-4-羟基-5-(羟甲基)-3-甲基四氢呋喃-2-基)嘧啶-2,4(1H,3H)-二酮|CsnPharm

CAS No.: 863329-66-2

索氟布韦中间体 Catalog No. CSN12940

Synonyms: RO 2433;GS-331007

PSI-6206, the deaminated derivative of PSI-6130, is a selective inhibitor of HCV NS5B polymerase and the EC50 for inhibition of HCV replicon is > 100 μM.

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技术信息

生物活性

描述The nonstructural protein NS5B has been characterized as an RNA-dependent RNA polymerase (RdRp) that is required for viral replication. This polymerase is considered to be an essential component in the HCV replication complex and therefore is an ideal target for drug discovery. PSI-6206, deaminated derivative of PSI-6130, is a potent and selective inhibitor of HCV NS5B polymerase acting as a potent anti-HCV agent. PSI-6206 demonstrated a potency in the HCV replicon assay with an EC₉₀ value of 5.40 ± 2.6 μM^[3].
参考文献

[1] Ma H, Jiang WR, et al. Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species. J Biol Chem. 2007 Oct 12;282(41):29812-20.
[2] Clark JL, Hollecker L, et al. Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication. J Med Chem. 2005 Aug 25;48(17):5504-8.
[3] Clark JL, Hollecker L, et al. Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication. J Med Chem. 2005 Aug 25;48(17):5504-8

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.8429 mL
- 19.2146 mL
- 38.4292 mL
- 5 mM
- 0.7686 mL
- 3.8429 mL
- 7.6858 mL
- 10 mM
- 0.3843 mL
- 1.9215 mL
- 3.8429 mL

技术信息

CAS号

863329-66-2

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C10H13FN2O5

运输

蓝冰

分子量

260.22

别名

RO 2433;GS-331007

溶解度

DMSO	52.0 mg/mL (199.8 mM)
Ethanol	24.0 mg/mL (92.2 mM)

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