|1-((5-氯萘-1-基)磺酰基)-1,4-二氮杂环庚烷盐酸盐|CsnPharm

CAS No.: 105637-50-1

1-((5-Chloronaphthalen-1-yl)sulfonyl)-1,4-diazepane hydrochloride Catalog No. CSN23710

Synonyms: ML-9 hydrochloride

ML 9 a is myosin light chain kinase (MLCK) inhibitor. ML-9 enhances the anticancer activity of docetaxel, suggesting its potential application as an adjuvant to existing anticancer chemotherapy. The complex effect of ML-9 on autophagy and indentified ML-9 as an attractive tool for targeting autophagy in cancer therapy through dual inhibition of both the Akt pathway and the autophagy.

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技术信息

生物活性

描述The Ca²⁺/calmodulin-dependent myosin light-chain kinase (MLCK) pathway is considered the primary regulatory pathway for contraction of airway smooth muscle. ML-9 is a membrane-permeable organic substance that has been identified as an inhibitor of MLCK. ML-9 at a concentration of 30 or 100μM inhibited Ca²⁺ mobilization induced by a high concentration of K⁺, methacholine, and thapsigargin in guinea pig tracheal smooth muscle.^[2] ML-9 at 30μM reduced the phosphorylation of Akt in lymph node carcinoma of the prostate (LNCaP) cells. Treatment with ML-9 (1 – 50μM, 2 – 24h) also dose- and time-dependently increased the expression level of LC3-II in LNCaP cells. Treatment of LNCaP cells with 30μM ML-9 for 24h significantly induced prostate cancer cell death.^[1]
作用机制 ML-9 is a membrane-permeable organic substance that has been identified as an inhibitor of MLCK, Akt kinase, and stromal interaction molecule 1.^[1]
参考文献

[1] Kondratskyi A, Yassine M, Slomianny C, Kondratska K, Gordienko D, Dewailly E, Lehen'kyi V, Skryma R, Prevarskaya N. Identification of ML-9 as a lysosomotropic agent targeting autophagy and cell death. Cell Death Dis. 2014 Apr 24;5(4):e1193. doi: 10.1038/cddis.2014.156
[2] Ito S, Kume H, Honjo H, Kodama I, Katoh H, Hayashi H, Shimokata K. ML-9, a myosin light chain kinase inhibitor, reduces intracellular Ca2+ concentration in guinea pig trachealis. Eur J Pharmacol. 2004 Feb 23;486(3):325-33. doi: 10.1016/j.ejphar.2004.01.013

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.7679 mL
- 13.8393 mL
- 27.6786 mL
- 5 mM
- 0.5536 mL
- 2.7679 mL
- 5.5357 mL
- 10 mM
- 0.2768 mL
- 1.3839 mL
- 2.7679 mL

技术信息

CAS号

105637-50-1

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H18Cl2N2O2S

运输

蓝冰

分子量

361.29

别名

ML-9 hydrochloride

溶解度

DMSO	72.0 mg/mL (199.3 mM)
Ethanol	6.0 mg/mL (16.6 mM)

动物实验配方

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1-((5-Chloronaphthalen-1-yl)sulfonyl)-1,4-diazepane hydrochloride Catalog No. CSN23710

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