|1-(4-氯-3-(三氟甲基)苯基)-3-(4-(4-氰基苯氧基)苯基)脲|CsnPharm

CAS No.: 1313019-65-6

1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea Catalog No. CSN27573

Synonyms: STAT3-IN-7

STAT3-IN-7 is a Sorafenib analogue and potently inhibits the phosphorylation of STAT3. STAT3-IN-7 induces cell apoptosis through SHP-1 dependent STAT3 inactivation. STAT3-IN-7 does not inhibit kinase activity and has anticancer effects.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述The signal transducer and activator of transcription 3 (STAT3) is a transcription factor associated with liver injury, inflammation, and regeneration. SC-1 (which is STAT3-IN-7), an aryl sulfonamide azetidine compound, is an orally active STAT3 inhibitor. It is a derivative of the multiple tyrosine kinase inhibitor sorafenib, blocks STAT3 phosphorylation and activation, and induces apoptosis in hepatocellular carcinoma cell lines, and has anticancer activities. SC-1 had dose- and time-dependent effects against cell viability on HSC-T6, LX2, and mouse primary hepatic stellate cells (HSCs). Further, SC-1 down-regulated p-STAT3 and suppressed Mcl-1 and cyclin D1 in both HSC-T6 and LX2 cell lines in a dose-dependent manner. Moreover, SC-1–induced apoptosis was abolished in STAT3-overexpressing HSC cells. In hepatotoxic and cholestatic models, hepatic fibrosis significantly reduced after SC-1 treatment in terms of Metavir fibrosis score and collagen-positive area^[2].
参考文献

[1] Chun-Yu Liu, et al. Novel sorafenib analogues induce apoptosis through SHP-1 dependent STAT3 inactivation in human breast cancer cells. Breast Cancer Res. 2013;15(4):R63.
[2] Su TH, Shiau CW, Jao P, Liu CH, Liu CJ, Tai WT, Jeng YM, Yang HC, Tseng TC, Huang HP, Cheng HR, Chen PJ, Chen KF, Kao JH, Chen DS. Sorafenib and its derivative SC-1 exhibit antifibrotic effects through signal transducer and activator of transcription 3 inhibition. Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7243-8.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3159 mL
- 11.5796 mL
- 23.1591 mL
- 5 mM
- 0.4632 mL
- 2.3159 mL
- 4.6318 mL
- 10 mM
- 0.2316 mL
- 1.1580 mL
- 2.3159 mL

技术信息

CAS号	1313019-65-6	储存条件	粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C21H13ClF3N3O2	运输	蓝冰
分子量	431.80	别名	STAT3-IN-7

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea Catalog No. CSN27573

靶点选择性

请登录您的专属账户

确认信息