|三环[3,3,1,13,7]癸烷-1-胺盐酸盐|CsnPharm

CAS No.: 665-66-7

1-Adamantanamine HCl/1-金刚烷胺盐酸盐 Catalog No. CSN10011

Synonyms: 1-Adamantanamine hydrochloride;1-Adamantylamine hydrochloride;1-Aminoadamantane hydrochloride

Amantadine HCl is an antiviral and an antiparkinsonian drug. It is used to treat or prevent infections of the respiratory tract caused by a certain virus.

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生物活性

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技术信息

生物活性

描述1-Adamantanamine Hydrochloride (amantadine hydrochloride), as a pro-dopaminergic drug and as an N-methyl-D-aspartate antagonist, makes amantadine an interesting candidate to improve consciousness and responsiveness in individuals with DOC (disorders of consciousness), including vegetative state and minimally conscious state^[3]. 1-Adamantanamine hydrochloride (aminoadamantane) has been shown to inhibit the multiplication of influenza A viruses in cell cultures, organ cultures and experimentally infected mice. In a double-blind, placebo-controlled investigation of aminoadamantane given prophylactically, in doses of 100 mg every 12 hours for 10 days, no protective effect of the drug was demonstrated^[4]. I-Adamantanamine hydrochloride, added to chick embryo cells, inhibited focus production upon subsequent inoculation of the cells with Rous and Esh sarcoma viruses. 1-adamantanamine hydrochloride are capable of supporting viral replication, the drug inhibits growth of two oncogenic viruses by prevention of virus penetration, but not by a virucidal effect or cell intoxication^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00513292	HER2/Neu Positive ... more >> Stage IA Breast Cancer Stage IB Breast Cancer Stage II Breast Cancer Stage IIIA Breast Cancer Collapse <<	Phase 3	Unknown	-	-
NCT01441986	Type 2 Diabetes Mellitus	Phase 2	Completed	-	Germany ... more >> Profil Institute for Metabolic Research Neuss, NRW, Germany, 41460 Collapse <<
NCT00513292	-	-	Unknown	-	-

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.3274 mL
- 26.6369 mL
- 53.2738 mL
- 5 mM
- 1.0655 mL
- 5.3274 mL
- 10.6548 mL
- 10 mM
- 0.5327 mL
- 2.6637 mL
- 5.3274 mL

技术信息

CAS号

665-66-7

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C10H18ClN

运输

蓝冰

分子量

187.71

别名

1-Adamantanamine hydrochloride;1-Adamantylamine hydrochloride;1-Aminoadamantane hydrochloride;Adamantylamine HCl;Amantadine HCl;ADS-5102 HCl;Aminoadamantane HCl;1-Adamantanamine HCl;1-Adamantylamine HCl;1-Aminoadamantane HCl;NSC 83653;Amantadine (hydrochloride);Adamantylamine;Aminoadamantane;ADS-5102;EXP 105-1;GP 38026;Influenol;Midantan;Midantane;Mydantane;Symadine;Symmetrel;Trivaline;Virasol;Viregyt;Virofral;Virosol;盐酸金刚烷胺

溶解度

DMSO	38.0 mg/mL (202.4 mM)
Water	37.0 mg/mL (197.1 mM)
Ethanol	37.0 mg/mL (197.1 mM)

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00513292	HER2/Neu Positive ... more >> Stage IA Breast Cancer Stage IB Breast Cancer Stage II Breast Cancer Stage IIIA Breast Cancer Collapse <<	Phase 3	Unknown	-	-
NCT01441986	Type 2 Diabetes Mellitus	Phase 2	Completed	-	Germany ... more >> Profil Institute for Metabolic Research Neuss, NRW, Germany, 41460 Collapse <<
NCT00513292	-	-	Unknown	-	-
NCT01071395	Parkinson's Disease	Phase 4	Completed	-	United States, Alabama ... more >> University of Alabama-Birmingham (UAB) Birmingham, Alabama, United States, 35043 United States, Florida University of South Florida Tampa, Florida, United States, 33606 United States, Illinois Rush University Medical Center Chicago, Illinois, United States, 60612 United States, North Carolina Duke University Durham, North Carolina, United States, 27705 United States, Oregon Oregon Health & Science University (OHSU) Portland, Oregon, United States, 97239-9059 Austria Universitatsklinik fur Neurologie Innsbruck, Austria, 6020 Canada, Ontario Toronto Western Hospital (Movement Disorder Center) Toronto, Ontario, Canada, M5T2S8 France Centre d'investigation Clinique, CHU de Toulouse Toulouse Cedex 9, France, 31059 Collapse <<
NCT01071395	-	-	Completed	-	-
NCT00979251	Influenza	Phase 2	Completed	-	-
NCT01467258	Healthy Metabolism	Not Applicable	Completed	-	Canada, Manitoba ... more >> St. Boniface General Hospital Winnipeg, Manitoba, Canada, R2H 2A6 Collapse <<
NCT00975611	Schizophrenia ... more >> Schizoaffective Disorder Collapse <<	Phase 4	Terminated(The sponsor withdre... more >>w support due to slow accrual of eligible subjects.) Collapse <<	-	United States, Massachusetts ... more >> Freedom Trail Clinic Boston, Massachusetts, United States, 02459 Collapse <<
NCT00975611	-	-	Terminated(The sponsor withdre... more >>w support due to slow accrual of eligible subjects.) Collapse <<	-	-
NCT00416962	Healthy	Phase 1	Completed	-	United States, New Jersey ... more >> Novartis Investigative Site East Hanover, New Jersey, United States, 07936-1080 Collapse <<
NCT02566720	Acquired Brain Injury ... more >> Coma Persistent Vegetative State Minimally Conscious State Traumatic Brain Injury Collapse <<	Not Applicable	Unknown	June 2017	Canada, Ontario ... more >> Hamilton Health Sciences Hamilton, Ontario, Canada Collapse <<
NCT00779324	Brain Injury ... more >>Aggression Collapse <<	Not Applicable	Completed	-	United States, Indiana ... more >> Indiana University and the Rehabilitation Hospital of Indiana Indianapolis, Indiana, United States, 46254 United States, Massachusetts Spaulding Rehabilitation Boston, Massachusetts, United States, 02114 United States, North Carolina Carolinas Rehabilitation Charlotte, North Carolina, United States, 28203 United States, Ohio The Ohio State University Columbus, Ohio, United States, 43210 United States, Texas TIRR Memorial Herman Houston, Texas, United States, 77030 United States, Washington University of Washington Seattle, Washington, United States, 98195 Collapse <<
NCT00755898	Cancer	Phase 2	Completed	-	Canada, Manitoba ... more >> University of Manitoba Winnipeg, Manitoba, Canada, R3E 0W3 Collapse <<
NCT02321761	Traumatic Brain Injury	Phase 4	Recruiting	December 1, 2018	Israel ... more >> Loewenstein Rehabilitation Center Recruiting Ra'anana, Israel Contact: Sara Lipkin, IRB coordinator +972-9-7709639 Mirp3@clalit.org.il Collapse <<
NCT00693121	Traumatic Brain Injury ... more >> Posttraumatic Confusional State Delirium Collapse <<	Phase 4	Unknown	June 2008	United States, Mississippi ... more >> Methodist Rehabilitation Center Jackson, Mississippi, United States, 39216 Collapse <<
NCT00627250	Irritable Mood ... more >> Aggression Traumatic Brain Injury Collapse <<	Not Applicable	Completed	-	-
NCT00970944	Traumatic Brain Injury	Phase 2 Phase 3	Completed	-	United States, Massachusetts ... more >> Braintree Rehabilitation Hospital Braintree, Massachusetts, United States, 02184 United States, Mississippi Methodist Rehabilitation Center Jackson, Mississippi, United States, 39216 United States, New York Columbia University New York, New York, United States, 10032 Sunnyview Rehabilitation Hospital Schenectady, New York, United States, 12308 United States, North Carolina Charlotte Rehabilitation Center Charlotte, North Carolina, United States, 28203 United States, Pennsylvania Moss Rehabilitation Research Institute Elkins Park, Pennsylvania, United States, 19027 Bryn Mawr Rehabilitation Hospital Malvern, Pennsylvania, United States, 19355 United States, Texas Texas NeuroRehabilitation Center Austin, Texas, United States, 78745 Denmark Hvidovre University Hospital Hvidovre, Denmark, DK 2650 Germany Neurologische Klinik Bad Aibling Bad Aibling, Germany, 83043 Fachkrankenhaus Neresheim Neresheim, Germany, 73450 Collapse <<
NCT00970944	-	-	Completed	-	-
NCT00796302	Attention Deficit Disorder Wit... more >>h Hyperactivity Collapse <<	Phase 4	Completed	-	United States, New York ... more >> State University of New York Stony Brook Stony Brook, New York, United States, 11794 United States, Ohio Case Western Reserve University Cleveland, Ohio, United States, 44106 Ohio State University Nisonger Center Columbus, Ohio, United States, 43210 United States, Pennsylvania University of Pittsburgh Pittsburgh, Pennsylvania, United States, 15213 Collapse <<
NCT00970944	-	-	Completed	-	-
NCT03436199	Walking Impairment ... more >> Multiple Sclerosis Collapse <<	Phase 3	Recruiting	September 1, 2019	-
NCT00970944	Traumatic Brain Injury	Phase 2 Phase 3	Completed	-	United States, Massachusetts ... more >> Braintree Rehabilitation Hospital Braintree, Massachusetts, United States, 02184 United States, Mississippi Methodist Rehabilitation Center Jackson, Mississippi, United States, 39216 United States, New York Columbia University New York, New York, United States, 10032 Sunnyview Rehabilitation Hospital Schenectady, New York, United States, 12308 United States, North Carolina Charlotte Rehabilitation Center Charlotte, North Carolina, United States, 28203 United States, Pennsylvania Moss Rehabilitation Research Institute Elkins Park, Pennsylvania, United States, 19027 Bryn Mawr Rehabilitation Hospital Malvern, Pennsylvania, United States, 19355 United States, Texas Texas NeuroRehabilitation Center Austin, Texas, United States, 78745 Denmark Hvidovre University Hospital Hvidovre, Denmark, DK 2650 Germany Neurologische Klinik Bad Aibling Bad Aibling, Germany, 83043 Fachkrankenhaus Neresheim Neresheim, Germany, 73450 Collapse <<
NCT00796302	-	-	Completed	-	-
NCT01397422	Dyskinesia Le... more >>vodopa Induced Dyskinesia Parkinson's Disease Collapse <<	Phase 2 Phase 3	Completed	-	-
NCT01397422	-	-	Completed	-	-
NCT02136914	-	-	Completed	-	-
NCT02202551	Dyskinesia Le... more >>vodopa Induced Dyskinesia (LID) Parkinson's Disease (PD) Collapse <<	Phase 3	Active, not recruiting	March 2018	-
NCT02471222	Walking Impairment ... more >> Multiple Sclerosis Collapse <<	Phase 2	Completed	-	United States, Arizona ... more >> Phoenix, Arizona, United States, 85018 United States, Colorado Aurora, Colorado, United States, 80045 United States, Florida Sarasota, Florida, United States, 34239 United States, Georgia Atlanta, Georgia, United States, 30309 United States, Illinois Northbrook, Illinois, United States, 60062 United States, Minnesota Rochester, Minnesota, United States, 55905 United States, Nebraska Lincoln, Nebraska, United States, 68506 United States, New Mexico Albuquerque, New Mexico, United States, 87131 United States, New York Patchogue, New York, United States, 11772 United States, North Carolina Raleigh, North Carolina, United States, 27607 United States, Ohio Cleveland, Ohio, United States, 44195 United States, Oklahoma Oklahoma City, Oklahoma, United States, 73104 United States, Tennessee Franklin, Tennessee, United States, 37064 United States, Texas Dallas, Texas, United States, 75214 United States, Washington Kirkland, Washington, United States, 11772 Collapse <<
NCT02274766	Dyskinesia Le... more >>vodopa-Induced Dyskinesia (LID) Parkinson's Disease (PD) Collapse <<	Phase 3	Completed	-	-
NCT02274766	-	-	Completed	-	-
NCT02153632	Parkinson's Disease ... more >> Levodopa Induced Dyskinesia (LID) Collapse <<	Phase 3	Terminated	-	-
NCT02153645	Parkinson's Disease ... more >> Levodopa Induced Dyskinesias (LID) Collapse <<	Phase 3	Terminated	-	-
NCT02136914	Dyskinesia Le... more >>vodopa Induced Dyskinesia (LID) Parkinson's Disease Collapse <<	Phase 3	Completed	-	-

1-Adamantanamine HCl/1-金刚烷胺盐酸盐 Catalog No. CSN10011

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