|1-(二苯甲基)-4-(3-苯基-2-丙烯基)哌嗪|CsnPharm

CAS No.: 298-57-7

桂利嗪 Catalog No. CSN12549

Synonyms: Stugeron|Dimitronal|Stutgin|Cinarizine;Stugeron;Dimitronal

Cinnarizine, an antihistamine, can block calcium channel and promote cerebral blood flow. It is used to treat post-trauma cerebral symptoms and cerebral arteriosclerosis.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Cinnarizine, an antagonist of H1-histamine receptors, was used to treat affected PJs (Pararescue)^[3]. Cinnarizine is a piperazine derivative with antihistaminic, antiserotonergic, antidopaminergic, and calcium channel-blocking activities^[4]. Cinnarizine (CIN), a poorly soluble drug with erratic bioavailability due to pH dependent solubility has limited advantage to formulate oral solid dosage forms in subject having low gastric acidity^[5]. The pharmacokinetics of cinnarizine following oral administration in dogs was found to fit the one-compartment mode. That of cinnarizine following intravenous injection in dogs was found to fit the two-compartment model. The relative bioavailability of oral administration was 46.4%. Cinnarizine cumulated significantly in dogs when 10mg/kg cinnarizine was injected repeatedly. Multiple-dose of cinnarizine over 6mg/kg induced reversible kidney injury in dogs^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03614715	Bioequivalence ... more >> Healthy Collapse <<	Phase 1	Recruiting	February 15, 2019	Finland ... more >> CRST Oy, Clinical Research Services Turku Itäinen Pitkäkatu 4 B, 3rd floor Recruiting Turku, Finland Collapse <<
NCT01198106	Simulator Sickness	Not Applicable	Unknown	September 2010	Israel ... more >> base 30 IAF Recruiting Yavne, Israel Collapse <<
NCT01939093	Methamphetamine-induced Psycho... more >>sis Collapse <<	Phase 4	Completed	-	Thailand ... more >> Thanyarak Institute on Drug Abuse Pathumthani, Thailand Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.7136 mL
- 13.5680 mL
- 27.1360 mL
- 5 mM
- 0.5427 mL
- 2.7136 mL
- 5.4272 mL
- 10 mM
- 0.2714 mL
- 1.3568 mL
- 2.7136 mL

技术信息

CAS号

298-57-7

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C26H28N2

运输

蓝冰

分子量

368.51

别名

Stugeron|Dimitronal|Stutgin|Cinarizine;Stugeron;Dimitronal;Stutgin;Dimitron;Folcodal;桂利嗪

溶解度

DMSO	11.0 mg/mL (29.8 mM)
Water	insoluble

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

桂利嗪 Catalog No. CSN12549

靶点选择性

请登录您的专属账户

确认信息