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CAS No.: 68890-66-4

吡罗克酮乙醇胺盐 Catalog No. CSN23230

Synonyms: Piroctone ethanolamine;吡罗克酮乙醇胺盐

Piroctone olamine is a pyridine derivate. It is known to have a fungicidal effect.

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技术信息

生物活性

描述Piroctone olamine is a pyridine derivate. It is known to have a fungicidal effect. For the C/P (climbazole/piroctone olamine) cream, the MICs were 0.625, 5, 0.625, and 2.5 mg/ml for Malassezia restricta, M. globosa, M. sympodialis, and M. slooffiae, respectively. Based on the reduced casual sebum level and extent of erythema, the antifungal activity of C/P cream against Malassezia species seems useful for the treatment of mild to moderate SD(Seborrheic dermatitis)^[1]. Piroctone olamine (PO) is an ethanolamine salt of the hydroxamic acid derivative Piroctone. All Candida strains show low minimum inhibitory concentrations (MICs) for Piroctone olamine (0.125-0.5 μg/mL) and Amphotericin B (AMB) (0.03-1 μg/mL) ^[2]. A comparable anti-fungal effectiveness for 0.5% piroctone olamine plus 0.45% climbazole and 1% zinc pyrithione, respectively. The shampoo formulation with 0.5% piroctone olamine and 0.45% climbazole effectively reduces the amount of dandruff and, at the same time, provides hair conditioning advantages^[3]. Moreover, Piroctone olamine demonstrated a major apoptotic activity in various human and murine myeloma and lymphoma cell lines, as well as in human primary cells. In vivo, tumor growth, as well as overall survival, was significantly reduced in mice treated with PO as compared to untreated mice^[4].
参考文献

[1] Youn HJ, Kim SY, Park M, et al. Efficacy and Safety of Cream Containing Climbazole/Piroctone Olamine for Facial Seborrheic Dermatitis: A Single-Center, Open-Label Split-Face Clinical Study. Ann Dermatol. 2016;28(6):733‐739
[2] do Couto FM, do Nascimento SC, Júnior SF, da Silva VK, Leal AF, Neves RP. Antifungal activity of the piroctone olamine in experimental intra-abdominal candidiasis. Springerplus. 2016;5:468. Published 2016 Apr 16
[3] Schmidt-Rose T, Braren S, Fölster H, et al. Efficacy of a piroctone olamine/climbazol shampoo in comparison with a zinc pyrithione shampoo in subjects with moderate to severe dandruff. Int J Cosmet Sci. 2011;33(3):276‐282
[4] Kim Y, Alpmann P, Blaum-Feder S, et al. Increased in vivo efficacy of lenalidomide by addition of piroctone olamine. In Vivo. 2011;25(1):99‐103

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.3510 mL
- 16.7549 mL
- 33.5097 mL
- 5 mM
- 0.6702 mL
- 3.3510 mL
- 6.7019 mL
- 10 mM
- 0.3351 mL
- 1.6755 mL
- 3.3510 mL

技术信息

CAS号

68890-66-4

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H30N2O3

运输

蓝冰

分子量

298.42

别名

Piroctone ethanolamine;吡罗克酮乙醇胺盐

溶解度

DMSO	115.0 mg/mL (385.4 mM)
Water	insoluble

动物实验配方

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