|1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐|CsnPharm

CAS No.: 23007-85-4

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine HCl/MPTP盐酸盐 Catalog No. CSN17271

Synonyms: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride;MPTP

MPTP HCl is a neurotoxin that causes symptoms similar to parkinson's disease by destroying dopamine-producing nerve cells in the substantia nigra. It is widely used in the study of various animal models of Parkinson's disease.

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描述Parkinson's disease (PD) is characterized by the selective loss of dopaminergic neurons in the substantia nigra (SN). MPTP is a neurotoxin that can induce symptoms similar to those observed in PD in humans, nonhuman primates, and mice. In addition, MPTP induces selective loss of dopaminergic neurons in mice SN^[3]. Mice in the MPTP group were intraperitoneally injected with 20 mg/kg MPTP hydrochloride dissolved in saline, with four injections at 3-hour intervals over a period of 1 day. The number of tyrosine hydroxylase-immunoreactive neurons in the MPTP group was significantly lower than in the normal group (P < 0.05), indicating successful establishment of the Parkinson's disease model. The changes in thioredoxin reductase 1 protein expression in the midbrain 7 days after the last injection of MPTP were detected. The MPTP-treated mice showed a 40% decrease in thioredoxin reductase 1 protein level compared with the normal mice (P < 0.05). Moreover, there was a pronounced reduction in thioredoxin reductase 1 mRNA level in MPTP-treated mice compared with normal mice (P < 0.05)^[4].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03382301	Renal Artery Stenosis	Phase 2	Not yet recruiting	December 2020	France ... more >> Service d'Exploration Fonctionnelle Rénale, Hôpital Edouard Herriot, Hospices Civils de Lyon Not yet recruiting Lyon, France, 69437 Contact: Sandrine LEMOINE, MD 472 110 263 ext +33 Sandrine.lemoine01@chu-lyon.fr Contact: Gabrielle Laetitia NORMAND, MD 472 110 263 ext +33 laetitia.normand@chu-lyon.fr Principal Investigator: Sandrine LEMOINE, MD Collapse <<

参考文献

[1] Liu Z, Jing Y, et al. Downregulation of thioredoxin reductase 1 expression in the substantia nigra pars compacta of Parkinson's disease mice. Neural Regen Res. 2013 Dec 15;8(35):3275-83.
[2] Nicotra A, Parvez S. Apoptotic molecules and MPTP-induced cell death. Neurotoxicol Teratol. 2002 Sep-Oct;24(5):599-605.
[3] Nicotra A, Parvez S. Apoptotic molecules and MPTP-induced cell death. Neurotoxicol Teratol. 2002 Sep-Oct;24(5):599-605. doi: 10.1016/s0892-0362(02)00213-1. PMID: 12200191.
[4] Liu Z, Jing Y, Yin J, Mu J, Yao T, Gao L. Downregulation of thioredoxin reductase 1 expression in the substantia nigra pars compacta of Parkinson's disease mice. Neural Regen Res. 2013 Dec 15;8(35):3275-83. doi: 10.3969/j.issn.1673-5374.2013.35.002. PMID: 25206649; PMCID: PMC4145943.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.7684 mL
- 23.8419 mL
- 47.6837 mL
- 5 mM
- 0.9537 mL
- 4.7684 mL
- 9.5367 mL
- 10 mM
- 0.4768 mL
- 2.3842 mL
- 4.7684 mL

技术信息

CAS号

23007-85-4

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C12H16ClN

运输

蓝冰

分子量

209.72

别名

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride;MPTP

溶解度

DMSO	18.0 mg/mL (85.8 mM)
Water	39.0 mg/mL (186.0 mM)
Ethanol	40.0 mg/mL (190.7 mM)

动物实验配方

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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine HCl/MPTP盐酸盐 Catalog No. CSN17271

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