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CAS No.: 26171-23-3

托麦汀 Catalog No. CSN22580

Synonyms: Tolectin;托麦汀

Tolmetin is a cyclooxygenase inhibitor used as a non-steroidal anti-inflammatory agent.

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技术信息

生物活性

描述1-Methyl-5-p-toluoylpyrrole-2-acetic acid (tolmetin) is a new nonsteroid anti-inflammatory agent. Tolmetin and aspirin had equal anti-inflammatory and analgesic effects in the treatment of juvenile rheumatoid arthritis. Elevations of transaminase values attributed to aspirin were not found with tolmetin^[2]. Anti-writhing ED50 of tolmetin sodium was 1.42 (0.82-2.91) and 92.0 (57.0-140) mg/kg when given intraperitoneally and intravenously, respectively, and the potency ratio of intraperitoneal to intravenous tolmetin sodium was 40.0 (18.5-80.2). When equipotent doses (5 mg/kg i.p.; 200 mg/kg i.v.) of tolmetin sodium were administered to the rat, the plasma tolmetin level after the intraperitoneal administration was less than one-fortieth that after the intravenous administration during the counting time of 20 min, while both the peritoneal exudate contents of tolmetin were nearly equal. The site of anti-writhing action of tolmetin sodium is in the peritoneum and that tolmetin sodium produces its anti-writhing action mainly by a peripheral mechanism in the rat^[3].
参考文献

[2] Levinson JE, Baum J, Brewer E Jr, Fink C, Hanson V, Schaller J. Comparison of tolmetin sodium and aspirin in the treatment of juvenile rheumatoid arthritis. J Pediatr. 1977 Nov;91(5):799-804
[3] Nakamura H, Shimizu M. Site of analgesic action of a non-steroidal, anti-inflammatory drug, tolmetin sodium, in rats. Br J Pharmacol. 1981 Jul;73(3):779-85

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.8868 mL
- 19.4341 mL
- 38.8682 mL
- 5 mM
- 0.7774 mL
- 3.8868 mL
- 7.7736 mL
- 10 mM
- 0.3887 mL
- 1.9434 mL
- 3.8868 mL

技术信息

CAS号

26171-23-3

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H15NO3

运输

蓝冰

分子量

257.28

别名

Tolectin;托麦汀

溶解度

DMSO	51.0 mg/mL (198.2 mM)

动物实验配方

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