CAS No.: 6698-26-6
2',5'-Dideoxyadenosine/2',5'-二脱氧腺苷 Catalog No. CSN27244
Synonyms: 2',5'-dideoxy Adenosine;2ʹ,5ʹ-dd-Ado;NSC 95943
2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site with an IC50 of 3 µM . 2',5'-Dideoxyadenosine is a nucleoside analog and exerts a potent antiadrenergic action in heart .
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 参考文献
- [1] Bushfield M, et al. Tissue levels, source, and regulation of 3'-AMP: an intracellular inhibitor of adenylyl cyclases. Mol Pharmacol. 1990 Dec;38(6):848-53.
- [2] Hartmann M, et al. Isoproterenol antagonistic effect of 2',5'-dideoxyadenosine in the isolated perfused guinea-pig heart. J Mol Cell Cardiol. 1993 Mar;25(3):331-8.
- [3] Zhao LX, et al. M1 muscarinic receptors regulate the phosphorylation of AMPA receptor subunit GluA1 via a signaling pathway linking cAMP-PKA and PI3K-Akt. FASEB J. 2019 May;33(5):6622-6631.
- [4] Leme Tdos S, et al. Role of prostaglandin/cAMP pathway in the diuretic and hypotensive effects of purified fraction of Maytenus ilicifolia Mart ex Reissek (Celastraceae). J Ethnopharmacol. 2013 Oct 28;150(1):154-61.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 6698-26-6 | 储存条件 |
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| 分子式 | C10H13N5O2 | 运输 | 蓝冰 | |
| 分子量 | 235.24 | 别名 | 2',5'-dideoxy Adenosine;2ʹ,5ʹ-dd-Ado;NSC 95943 |
