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CAS No.: 7235-40-7

β-胡罗卜素 Catalog No. CSN10423

Synonyms: β-胡萝卜素;Provitamin A;beta-Carotene

β-Carotene is a naturally occuring retinol (vitamin A) precursor found in plants and fruits, used to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria.

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述β-Carotene (beta-carotene), a carotenoid compound, is a naturally-occurring vitamin A precursor. β-Carotene is a modulator of reactive oxygen species (ROS), with antioxidant and antiinflammatory activities. Hmox1 (heme oxygenase 1) mRNA, but not Cox2 (cyclooxygenase-2) and Nos2 (nitric oxide synthase 2) mRNA, was up-regulated by 100 μM β-carotene and lycopene, and by 0.125% TBB (Tri-n-butyl borane). LPS-stimulated Cox2, Nos2 and Tnfa gene expression was inhibited by 50 μM β-carotene and lycopene, and by 0.5-1% TBB. Both β-carotene and lycopene had weak antioxidant activity, but β-carotene showed pro-oxidant activity at higher concentrations^[3]. beta-carotene significantly increased PPAR-gamma mRNA and protein levels in time-dependent manner. In addition, beta-carotene increased the cyclin-dependent kinase inhibitor p21(WAF1/CIP1) expression and decreased the prostanoid synthesis rate-limiting enzyme cyclooxygenase-2 expression. Further, reactive oxygen species (ROS) production was induced by beta-carotene, resulting in mitochondrial dysfunction and cytochrome C release^[4]. Furthermore, the combination of beta-carotene with ethanol results in hepatotoxicity. Moreover, in smokers who also consume alcohol, beta-carotene supplementation promotes pulmonary cancer and, possibly, cardiovascular complications. Thus ethanol, while promoting a deficiency of vitamin A also enhances its toxicity as well as that of beta-carotene^[5]. Supplementation with β-carotene increases the risk of lung cancer in smokers regardless of the tar or nicotine content of cigarettes smoked^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01290250	Overweight Ob... more >>esity Collapse <<	Not Applicable	Completed	-	Spain ... more >> Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology, Center for Biomedical Research, University of Granada, Spain, 18071 Collapse <<
NCT01488656	Inflammation	Not Applicable	Completed	-	-
NCT01951313	Will Consuming Eggs With a Mix... more >>ed Vegetable Salad Increase Carotenoid Absorption Collapse <<	Not Applicable	Completed	-	United States, Indiana ... more >> Purdue University West Lafayette, Indiana, United States, 47907 Collapse <<

更多
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.8626 mL
- 9.3132 mL
- 18.6264 mL
- 5 mM
- 0.3725 mL
- 1.8626 mL
- 3.7253 mL
- 10 mM
- 0.1863 mL
- 0.9313 mL
- 1.8626 mL

技术信息

CAS号

7235-40-7

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C40H56

运输

蓝冰

分子量

536.87

别名

β-胡萝卜素;Provitamin A;beta-Carotene

溶解度

DMSO	insoluble
Water	insoluble
Ethanol	insoluble

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT01290250	Overweight Ob... more >>esity Collapse <<	Not Applicable	Completed	-	Spain ... more >> Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology, Center for Biomedical Research, University of Granada, Spain, 18071 Collapse <<
NCT01488656	Inflammation	Not Applicable	Completed	-	-
NCT01951313	Will Consuming Eggs With a Mix... more >>ed Vegetable Salad Increase Carotenoid Absorption Collapse <<	Not Applicable	Completed	-	United States, Indiana ... more >> Purdue University West Lafayette, Indiana, United States, 47907 Collapse <<
NCT03442283	-	-	Active, not recruiting	June 2018	-
NCT01493297	Iron Absorption	Not Applicable	Completed	-	Venezuela ... more >> Venezuelan Institute for Scientific Research (IVIC) Caracas, Venezuela, 1020-A Collapse <<
NCT02276014	Beta-carotene Bioavailability ... more >> Vitamin A Deficiency Collapse <<	Not Applicable	Completed	-	United Kingdom ... more >> Newcastle NIHR Clinical Research Facility, Royal Victoria Infirmary Newcastle upon Tyne, Tyne & Wear, United Kingdom, NE1 4LP Collapse <<
NCT01726127	Dietary Modification	Not Applicable	Completed	-	United States, Wisconsin ... more >> University of Wisconsin Osteoporosis Clinical Research Program Clinic Madison, Wisconsin, United States, 53705 Collapse <<
NCT01628081	Psoriasis	Phase 3	Unknown	July 2014	Israel ... more >> The Bert W. Strassburger Lipid Center,Sheba Medical Center Recruiting Tel-Hashomer, Israel, 52621 Principal Investigator: Shoshna Greenberger, MD The Bert W. Strassburger Lipid Center Recruiting Tel-Hashomer, Israel, 52621 Sub-Investigator: Ofir Artzi, MD Collapse <<
NCT02018692	Retinitis Pigmentosa	Phase 1 Phase 2	Not yet recruiting	December 31, 2019	Israel ... more >> Goldschleger Eye Research Institute, Sheba Medical Center, Not yet recruiting Tel Hashomer, Israel, 52621 Contact: Ygal Rotenstreich, MD 972-3-530-2880 ygal.rotenstreich@sheba.health.gov.il Collapse <<
NCT01256697	Retinitis Pigmentosa	Not Applicable	Completed	-	Israel ... more >> Sheba Medical Center Tel Hashomer, Israel Collapse <<
NCT01922713	Vitamin A Deficiency	Not Applicable	Completed	-	Zambia ... more >> Center for Human Nutrition Mkushi, Mkushi District, Zambia Collapse <<
NCT03005496	PreTerm Birth	Phase 4	Completed	-	-
NCT01121081	Psoriasis	Phase 3	Withdrawn(no patients enrolled... more >>) Collapse <<	January 2012	Israel ... more >> Sheba Medical Center Ramat Gan, Israel, 52621 Collapse <<
NCT02060279	Pediatric Obesity	Not Applicable	Completed	-	United States, Florida ... more >> Nemours Children's Clinic Jacksonville, Florida, United States, 32207 Collapse <<
NCT00680355	Healthy	Not Applicable	Completed	-	United States, Massachusetts ... more >> USDA Human Nutrition Research Center on Aging at Tufts Uni Boston, Massachusetts, United States, 02111 Collapse <<
NCT03366584	Hyaline Membrane Disease ... more >> Necrotizing Enterocolitis of Newborn Collapse <<	Phase 4	Recruiting	June 2019	Indonesia ... more >> Cipto Mangunkusumo General Hospital Recruiting Jakarta, DKI Jakarta, Indonesia, 12440 Contact: Yuyun Lisnawati, Consultant +628161841987 yulisna.er@gmail.com Collapse <<
NCT01680510	Retinitis Pigmentosa	Phase 2 Phase 3	Recruiting	December 2018	Israel ... more >> Sheba Medical Center Recruiting Tel Hashomer, Israel, 52621 Contact: Ygal Rotenstreich, Dr. 972-3-5302880 Principal Investigator: Ygal Rotenstreich, Dr. Collapse <<
NCT02373943	Healthy	Not Applicable	Completed	-	Spain ... more >> Hospital Universitari Arnau de Vilanova LLeida, Spain, 25110 Collapse <<
NCT01477112	Diabetes Mellitus ... more >> Oxidative Stress Iron Metabolism Disorders Collapse <<	Not Applicable	Completed	-	Venezuela ... more >> Hospital Baudilio Lara Barquisimeto, Lara, Venezuela Collapse <<
NCT01695148	Vitamin A Deficiency ... more >> Low Serum Retinol Collapse <<	Phase 3	Completed	-	Zambia ... more >> JHU Office Mkushi, Zambia Collapse <<

β-胡罗卜素 Catalog No. CSN10423

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