|2,2`-亚甲基双(4-氯苯酚)|CsnPharm

CAS No.: 97-23-4

2,2'-亚甲基双 Catalog No. CSN16068

Synonyms: 双氯酚;DDM;二氯酚

Dichlorophen is an anticestodal agent.

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技术信息

生物活性

描述Dichlorophen is a chlorophenol fungicide. Dichlorophen ingestion results in life-threatening multiorgan dysfunction including rapid onset of caustic digestive lesions, diarrhea, liver enzyme disturbances, as well as acute kidney injury and rhabdomyolysis. Recovery can be complete if prompt supportive management is provided^[2]. The in vitro and in vivo efficacy of dichlorophen (DCP), an antiparasitic agent for intestinal parasites, and silica nanoparticles modified with DCP (NP-DCP) was evaluated against E. multilocularis larval stage. Both formulations showed a time and dose-dependent in vitro effect against protoscoleces. In vivo studies demonstrated that the NP-DCP (4 mg kg-1) had similar efficacy to ABZ (25 mg kg-1) and greater activity than the free DCP^[3]. Dichlorophen is advocated for tape worm, but was found to reduce the ova count by 83.3% and repeat treatment completely eradicated infection with F. buski^[4].
参考文献

[1] Shi H, Peng J, et al. Laccase-catalyzed removal of the antimicrobials chlorophene and dichlorophen from water: Reaction kinetics, pathway and toxicity evaluation. J Hazard Mater. 2016 Nov 5;317:81-89.
[2] Langrand J, Moesch C, Le Grand R, et al. A life-threatening dichlorophen poisoning case: clinical features and kinetics study. Clin Toxicol (Phila). 2013;51(3):178-181
[3] Fabbri J, Pensel PE, Albani CM, Arce VB, Mártire DO, Elissondo MC. Drug repurposing for the treatment of alveolar echinococcosis: in vitro and in vivo effects of silica nanoparticles modified with dichlorophen. Parasitology. 2019;146(13):1620-1630
[4] Idris M, Rahman KM, Muttalib MA, Azad Khan AK. The treatment of fasciolopsiasis with niclosamide and dichlorophen. J Trop Med Hyg. 1980;83(2):71-74

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.7158 mL
- 18.5788 mL
- 37.1577 mL
- 5 mM
- 0.7432 mL
- 3.7158 mL
- 7.4315 mL
- 10 mM
- 0.3716 mL
- 1.8579 mL
- 3.7158 mL

技术信息

CAS号

97-23-4

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C13H10Cl2O2

运输

蓝冰

分子量

269.12

别名

双氯酚;DDM;二氯酚

溶解度

DMSO	350.0 mg/mL (1300.5 mM)
Water	insoluble

动物实验配方

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2,2'-亚甲基双 Catalog No. CSN16068

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