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CAS No.: 15318-45-3

甲砜霉素 Catalog No. CSN11474

Synonyms: Thiophenicol;Dextrosulphenidol;NSC 522822

Thiamphenicol is a chloramphenicol antibiotic and a glutamate transporter upregulating agent.

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实验方案

技术信息

生物活性

描述Thiamphenicol is an antimicrobial antibiotic and a methyl-sulfonyl analogue of chloramphenicol. Thiamphenicol showed a significant PAE (0.33 to 2.9h) on all pathogens studied and a powerful bactericidal effect against beta-lactamase-positive and -negative H. influenzae^[2]. Moreover, the significant better curative effect of TAF (Thiamphenicol) on BDD M2 (bovine digital dermatitis) lesions was small, compared with ENG (oxytetracycline)^[3]. The activity of thiamphenicol was greater than that of erythromycin against H. influenzae and streptococci and equivalent versus Branhamella catarrhalis. In comparison with amoxicillin, the activity of thiamphenicol was higher against H. influenzae and B. catarrhalis and slightly lower against streptococci^[4].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00958503	Healthy	Phase 1	Completed	-	Belgium ... more >> SGS Research Unit - Stuivenberg Antwerpen, Belgium Collapse <<

参考文献

[1] Marchese A, Debbia EA, et al. In vitro activity of thiamphenicol against multiresistant Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus in Italy. J Chemother. 2002 Dec;14(6):554-61.
[2] Marchese A, Debbia EA, Tonoli E, Gualco L, Schito AM. In vitro activity of thiamphenicol against multiresistant Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus in Italy. J Chemother. 2002 Dec;14(6):554-61. doi: 10.1179/joc.2002.14.6.554. PMID: 12583545.
[3] Holzhauer M, Ploegmakers-van Deventer R, Smits D, Swart W. Comparing the curative efficacy of topical treatment with thiamphenicol and oxytetracycline on digital dermatitis lesions in dairy cattle. Vet Rec. 2017 May 20;180(20):500. doi: 10.1136/vr.103758. Epub 2017 May 2. PMID: 28465327.
[4] Albini E, Belluco G, Berton M, Schioppacassi G, Ungheri D. In vitro antibacterial activity of thiamphenicol glycinate acetylcysteinate against respiratory pathogens. Arzneimittelforschung. 1999 Jun;49(6):533-7. doi: 10.1055/s-0031-1300456. PMID: 10417871.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8072 mL
- 14.0362 mL
- 28.0724 mL
- 5 mM
- 0.5614 mL
- 2.8072 mL
- 5.6145 mL
- 10 mM
- 0.2807 mL
- 1.4036 mL
- 2.8072 mL

技术信息

CAS号

15318-45-3

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C12H15Cl2NO5S

运输

蓝冰

分子量

356.22

别名

Thiophenicol;Dextrosulphenidol;NSC 522822;WIN 5,603-2;Descocin;Hyrazin;Masatirin;Urfamycine;甲砜霉素

溶解度

DMSO	150.0 mg/mL (421.1 mM) warming
Water	insoluble

动物实验配方

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