|2-((5-溴-4-(4-环丙基萘-1-基)-4H-1,2,4-三唑-3-基)硫代)乙酸|CsnPharm

CAS No.: 878672-00-5

雷西那德 Catalog No. CSN16882

Synonyms: RDEA594;RDEAi594;Zurampic

Lesinurad is a URAT1 inhibitor with IC50 of 3.5 µM. It acts as a transporter that regulates uric acid excretion in kidney.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Lesinurad is an inhibitor of URAT1 (IC50 = 3.5 µM), which is a transporter in the kidney that regulates uric acid excretion from the body.
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02028689	Healthy	Phase 1	Completed	-	United States, Michigan ... more >> Kalamazoo, Michigan, United States, 49007 Collapse <<
NCT00955981	Hyperuricemia	Phase 2	Completed	-	-
NCT01510158	Gout	Phase 3	Completed	-	-

更多
参考文献

[1] Tan P K, Hyndman D, Miner J N. SAT0521 Lesinurad, an Inhibitor of the Uric Acid Transporter URAT1 and A Potential Therapy for Gout, Requires URAT1 Phenylalanine 365 for High Affinity Inhibition[J] . Annals of the Rheumatic Diseases, 2014, 73(Suppl 2):780-780.
[2] Zhou D. RDEA594, a Potential Uric Acid Lowering Agent through Inhibition of Uric Acid Reuptake, Shows Better Pharmacokinetics than its Prodrug RDEA806[J] . Arthritis & Rheumatology, 2008.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4735 mL
- 12.3676 mL
- 24.7353 mL
- 5 mM
- 0.4947 mL
- 2.4735 mL
- 4.9471 mL
- 10 mM
- 0.2474 mL
- 1.2368 mL
- 2.4735 mL

技术信息

CAS号

878672-00-5

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C17H14BrN3O2S

运输

蓝冰

分子量

404.28

别名

RDEA594;RDEAi594;Zurampic;雷西那德

溶解度

DMSO	78.0 mg/mL (192.9 mM)
Water	Insoluble
Ethanol	54.0 mg/mL (133.6 mM)

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02028689	Healthy	Phase 1	Completed	-	United States, Michigan ... more >> Kalamazoo, Michigan, United States, 49007 Collapse <<
NCT00955981	Hyperuricemia	Phase 2	Completed	-	-
NCT01510158	Gout	Phase 3	Completed	-	-
NCT01001338	Gout	Phase 2	Completed	-	-
NCT01510769	Tophaceous Gout	Phase 3	Completed	-	-
NCT01510769	-	-	Completed	-	-
NCT01510158	-	-	Completed	-	-
NCT01493531	Gout	Phase 3	Completed	-	-
NCT01884272	Gout	Phase 1	Completed	-	United States, Michigan ... more >> Kalamazoo, Michigan, United States, 49007 Collapse <<
NCT01493531	-	-	Completed	-	-
NCT02581553	Healthy	Phase 1	Completed	-	United States, Texas ... more >> Austin, Texas, United States, 78744 Collapse <<
NCT01982201	Healthy	Phase 1	Completed	-	United States, Michigan ... more >> Kalamazoo, Michigan, United States, 49007 Collapse <<
NCT01744379	Gout	Phase 1	Completed	-	United States, California ... more >> Glendale, California, United States, 91206 Collapse <<
NCT02888054	Healthy	Phase 1	Completed	-	United States, Texas ... more >> Austin, Texas, United States, 78744 Collapse <<
NCT01508702	-	-	Completed	-	-
NCT01808144	-	-	Completed	-	-
NCT01650246	Gout	Phase 3	Completed	-	-
NCT03272425	Gout	Phase 1	Completed	-	Brazil ... more >> CAEP - Centro Avançado de Estudos e Pesquisas Ltda. Campinas, Sao Paulo, Brazil Collapse <<
NCT01808144	Gout	Phase 3	Completed	-	-
NCT01986556	Healthy	Phase 1	Completed	-	United States, California ... more >> Glendale, California, United States, 91206 Collapse <<
NCT01808131	Gout	Phase 3	Completed	-	-
NCT02127775	Healthy	Phase 1	Completed	-	United States, Texas ... more >> Austin, Texas, United States, 78744 Collapse <<
NCT01508702	Gout	Phase 3	Completed	-	-
NCT03226899	Gout Chronic ... more >>Kidney Disease (CKD) Collapse <<	Phase 4	Recruiting	December 2022	-
NCT02039700	Healthy	Phase 1	Completed	-	United States, Wisconsin ... more >> Madison, Wisconsin, United States, 53704 Collapse <<
NCT01908257	Healthy	Phase 1	Completed	-	United States, California ... more >> Cypress, California, United States, 90630 Collapse <<
NCT01650246	-	-	Completed	-	-

雷西那德 Catalog No. CSN16882

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