|2-(10-羟基癸基)-5,6-二甲氧基-3-甲基环己-2,5-二烯-1,4-二酮|CsnPharm

CAS No.: 58186-27-9

艾地苯醌 Catalog No. CSN11185

Synonyms: CV-2619;Mnesis;Catena

Idebenone, a synthetic analog of coenzyme Q10 (CoQ10), can protect mitochondrial membranes against lipid peroxidation and also used as a neuroprotective agent.

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生物活性

实验方案

技术信息

生物活性

描述Idebenone is a synthetic variant of coenzyme Q10 (CoQ10), which targets mitochondria, preserves mitochondrial function, and confers cytoprotection. In this way, idebenone has neuroprotective effects and has applications in Friedreich ataxia.
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03014856	-	-	Completed	-	-
NCT00224640	Friedreich Ataxia	Phase 1 Phase 2	Completed	-	France ... more >> Necker Hospital Paris, France, 75015 Collapse <<
NCT03014908	-	-	Completed	-	Belgium ... more >> Hasselt University Hasselt, Limburg, Belgium, 3500 Collapse <<

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参考文献

[1] Rego AC, Santos MS, Oliveira CR. Influence of the antioxidants vitamin E and idebenone on retinal cell injury mediated by chemical ischemia, hypoglycemia, or oxidative stress. Free Radic Biol Med. 1999 Jun;26(11-12):1405-17.
[2] Yamada K, Tanaka T, et al. Protective effects of idebenone and alpha-tocopherol on beta-amyloid-(1-42)-induced learning and memory deficits in rats: implication of oxidative stress in beta-amyloid-induced neurotoxicity in vivo. Eur J Neurosci. 1999 Jan;11(1):83-90.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.9547 mL
- 14.7737 mL
- 29.5475 mL
- 5 mM
- 0.5909 mL
- 2.9547 mL
- 5.9095 mL
- 10 mM
- 0.2955 mL
- 1.4774 mL
- 2.9547 mL

技术信息

CAS号

58186-27-9

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C19H30O5

运输

蓝冰

分子量

338.44

别名

CV-2619;Mnesis;Catena;Raxone;Sovrima;艾地苯醌

溶解度

DMSO	68.0 mg/mL (200.9 mM)
Water	Insoluble
Ethanol	68.0 mg/mL (200.9 mM)

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT03014856	-	-	Completed	-	-
NCT00224640	Friedreich Ataxia	Phase 1 Phase 2	Completed	-	France ... more >> Necker Hospital Paris, France, 75015 Collapse <<
NCT03014908	-	-	Completed	-	Belgium ... more >> Hasselt University Hasselt, Limburg, Belgium, 3500 Collapse <<
NCT01421381	-	-	Completed	-	Canada, Quebec ... more >> Hôpital Notre-Dame (CHUM) Montreal,, Quebec, Canada, H2L 4M1 Germany Friedrich Baur Institut Neurologische Klinik und Poliklinik München, Germany, D-80336 United Kingdom Biomedical Research Centre, The Medical School Newcastle upon Tyne, United Kingdom, NE2 4HH Collapse <<
NCT02774005	Leber's Hereditary Optic Neuro... more >>pathy (LHON) Collapse <<	Phase 4	Recruiting	February 2021	-
NCT01495715	Leber's Hereditary Optic Neuro... more >>pathy Collapse <<	Phase 3	Withdrawn	-	-
NCT00015808	Friedreich Ataxia	Phase 1	Completed	-	United States, Maryland ... more >> National Institute of Neurological Disorders and Stroke (NINDS) Bethesda, Maryland, United States, 20892 Collapse <<
NCT02887443	Drug-Drug Interaction	Phase 1	Completed	-	France ... more >> Eurofins Optimed Gières, France, 38610 Collapse <<
NCT00078481	Friedreich Ataxia	Phase 1	Completed	-	United States, Maryland ... more >> National Institute of Neurological Disorders and Stroke (NINDS) Bethesda, Maryland, United States, 20892 Collapse <<
NCT00654784	Duchenne Muscular Dystrophy (D... more >>MD) Collapse <<	Phase 2	Completed	-	Belgium ... more >> Children's Hospital, University Hospital Leuven, Belgium Collapse <<
NCT02771379	-	-	Recruiting	February 2021	Austria ... more >> Universitaetsklinikum Graz Recruiting Graz, Austria, 8036 Principal Investigator: Mona Schneider, MD Medical University of Vienna Recruiting Vienna, Austria Principal Investigator: Berthold Pemp, MD France CHU de Nîmes - Hôpital Carémeau Recruiting Nîmes, Gard, France, 30029 Principal Investigator: Luc Jeanjean, MD CHU Angers - Hôpital Hôtel Dieu Recruiting Angers, Maine Et Loire, France, 49033 Principal Investigator: Christophe Verny, MD Hopital Roger Salengro - CHU Lille Recruiting Lille, Nord, France, 59037 Principal Investigator: Sabine Defoort Delemmes, MD Hôpital Européen Georges Pompidou Recruiting Paris, Paris Cedex 15, France, 75908 Principal Investigator: Christophe Orssaud, MD CHU Amiens - Centre Saint Victor Recruiting Amiens, Somme, France, 80054 Principal Investigator: Solange Milazzo, MD Hopital Neurologique Pierre Wertheimer Recruiting Lyon Cedex, France, 69677 Principal Investigator: Damien Biotti, MD Hospices Civils de Lyon Recruiting Lyon, France, 69002 Principal Investigator: Caroline Tilikete, MD Centre Hospitalier National d'Ophtalmologie (CHNO) des Quinze-Vingts Recruiting Paris, France, 75012 Principal Investigator: Catherine Vignal, MD Fondation Ophtalmologique Adolphe de Rothschild Recruiting Paris, France, 75019 Principal Investigator: Rabih Hage, MD Germany Julius Maximilians University Recruiting Wuerzburg, Baden Wuerttemberg, Germany, 97070 Principal Investigator: Thomas Ach, MD Charite - Campus Virchow-Klinikum Recruiting Berlin, Germany, 13353 Principal Investigator: Uwe Pleyer, MD Universitaetsklinikum Essen Recruiting Essen, Germany Principal Investigator: Michael Oeverhaus, MD Universitaetsklinikum Freiburg Recruiting Freiburg, Germany Principal Investigator: Wolf Lagreze Universitaetsklinikum Hamburg-Eppendorf Recruiting Hamburg, Germany, 20246 Principal Investigator: Martin Spitzer, MD Universitaetsklinikum Heidelberg Recruiting Heidelberg, Germany Principal Investigator: Klaus Rohrschneider, MD Friedrich-Baur-Institut Recruiting Munich, Germany Principal Investigator: Thomas Klopstock Universitaetsklinikum Muenster Recruiting Munster, Germany Principal Investigator: Nicole Eter, MD Universitaetsklinikum Neubrandenburg Recruiting Neubrandenburg, Germany Principal Investigator: Herbert Jaegle, MD Universitaetsklinikum Regensburg Recruiting Regensburg, Germany Principal Investigator: Helmut Hoeh, MD Greece Athens Ophthalmological Center Recruiting Athens, Greece, 11528 Principal Investigator: Agathi Kouri, MD Italy Università di Bologna-Clinica Neurologica-Dipartimento di Scienze Neurologiche Not yet recruiting Bologna, Italy, 40123 Principal Investigator: Valerio Carelli, MD Ospedale San Raffaele Recruiting Milano, Italy, 20132 Principal Investigator: Francesco Maria Bandello, MD Azienda Ospedaliera S. Camillo Forlanini Not yet recruiting Rome, Italy, 00152 Principal Investigator: Anna De Negri, MD Netherlands Universitair Medisch Centrum Groningen Recruiting Groningen, Netherlands, 9713 GZ Principal Investigator: Jan-Willem Pott, MD Maastricht University Medical Center Not yet recruiting Maastricht, Netherlands, 6211 LK Principal Investigator: Noël Bauer, MD Collapse <<
NCT01854359	Multiple Sclerosis ... more >> Primary Progressive Multiple Sclerosis Collapse <<	Phase 1 Phase 2	Active, not recruiting	August 1, 2019	United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse <<
NCT00537680	Friedreich's Ataxia	Phase 3	Completed	-	United States, California ... more >> David Geffen School of Medicine, UCLA Los Angeles, California, United States, 90095-1769 United States, Pennsylvania The Children's Hopsital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 Collapse <<
NCT00654784	-	-	Completed	-	-
NCT00950248	Primary Progressive Multiple S... more >>clerosis Collapse <<	Phase 1 Phase 2	Completed	-	United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse <<
NCT00537680	-	-	Completed	-	-
NCT00229632	Friedreich Ataxia	Phase 2	Completed	-	United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse <<
NCT00747487	Leber's Hereditary Optic Neuro... more >>pathy Collapse <<	Phase 2	Completed	-	Canada, Quebec ... more >> Unité de recherche clinique Ophtalmologie- Hopital Notre-Dame Montreal, Quebec, Canada, H2L 4M1 Germany Klinikum der Universität München - Grosshadern, Neurologische Klinik und Poliklinik Munich, Germany, 81377 United Kingdom Clinical Research Facility, 4th Floor Leazes Wing, Royal Victoria Infirmary Newcastle Upon Tyne, United Kingdom, NE1 4LP Collapse <<
NCT02814019	Duchenne Muscular Dystrophy (D... more >>MD) Collapse <<	Phase 3	Recruiting	August 2019	-
NCT00905268	-	-	Completed	-	-
NCT00697073	Friedreich's Ataxia	Phase 3	Completed	-	United States, California ... more >> David Geffen School of Medicine, UCLA Los Angeles, California, United States, 90095-1769 United States, Pennsylvania The Children's Hopsital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 Collapse <<
NCT00697073	-	-	Completed	-	-
NCT01027884	Muscular Dystrophy, Duchenne ... more >> Ambulatory Care Collapse <<	Phase 3	Completed	-	-
NCT01027884	-	-	Completed	-	-
NCT00905268	Friedreich's Ataxia	Phase 3	Completed	-	Austria ... more >> Universitätsklinik Innsbruck Innsbruck, Austria, 6020 Belgium Hôpital Erasme - Université Libre de Bruxelles Bruxelles, Belgium, 1070 France Hôpital de la Salpêtrière - INSERM U679, Neurologie et Thérapeutique expérimentale Paris, France, 75651 Germany HELIOS Klinikum BerlinBuch Berlin, Germany, 13125 Neurologische Universitätsklinik und Poliklinik- Universitätsklinikum Bonn Bonn, Germany, 53105 Klinik II, Neuropädiatrie u.Muskelerkrankungen- Universitätsklinik Freiburg Freiburg, Germany, 79106 Zentrum für Neurologische Medizin Göttingen, Germany, 37073 UKE Hamburg Neuropädiatrie-Zentum für Frauen, Kinder und Jugendmedizin Hamburg, Germany, 20246 Neurologische Klinik- klinikum Grosshadern München, Germany, 81377 Neurologische Universitätsklinik und Poliklinik Tübingen, Germany, 72076 Netherlands University Medical Center Groningen Groningen, Netherlands, 9700 RB United Kingdom National Hospital for Neurology & Neurosurgery London, United Kingdom, WC1N 3BG University of Newcastle upon Tyne -Mitochondrial Research Group Newcastle, United Kingdom, NE2 4HH Collapse <<
NCT00993967	Freidreich's Ataxia	Phase 3	Completed	-	Austria ... more >> Universitätsklinik Innsbruck Innsbruck, Austria Belgium Hôpital Erasme - Univeristé Libre de Bruxelles Bruxelles, Belgium, 1070 France Hôpital de la Salpétrière - INSERM U679, Neurologie et Thérapeutique expérimentale Paris, France, 75651 Germany HELIOS Klinikum Berlin Berlin, Germany, 13125 Neurologische Universitätsklinik und Ploklinik - Universitätsklimikum Bonn Bonn, Germany, 53105 Klinik II, Neuropädiatrie und Muskelerkrankungen - Universitätsklinik Freiburg Freiburg, Germany, 79106 Zentrum für Neurologische Medizin Göttingen, Germany, 37073 UKE Hamburg Neuropädiatrie - Zentrum für Frauen, Kinder und Jugendmedizin Hamburg, Germany, 20246 Neurologische Klinik - Klinikum Grosshadern München, Germany, 81377 Neurologische Universitätsklinik und Poliklinik Tübingen, Germany, 72076 Netherlands University medical Center Groningen Groningen, Netherlands, 9700 RB Collapse <<
NCT00758225	Duchenne Muscular Dystrophy	Phase 2	Completed	-	Belgium ... more >> University Hospitals Leuven Leuven, Belgium, 3000 Collapse <<
NCT00887562	-	-	Completed	-	-
NCT00993967	-	-	Completed	-	-
NCT03727295	Oxidative Stress is an Importa... more >>nt Cause of Parkinson's Disease Collapse <<	Phase 4	Not yet recruiting	May 30, 2021	-
NCT01303406	Friedreich's Ataxia	Phase 3	Completed	-	Austria ... more >> Innsbruck, Austria Germany Bonn, Germany München, Germany Tübingen, Germany Netherlands Groningen, Netherlands United Kingdom The National Hospital, University College London London, United Kingdom, WC 1N 3BG Collapse <<
NCT03433807	-	-	-	-	United States, Arizona ... more >> Phoenix Children's Hospital Phoenix, Arizona, United States, 85016 Contact: Saunder Bernes, MD United States, Iowa University of Iowa Iowa City, Iowa, United States, 52242 Contact: Kathy Mathews, MD United States, Maryland Kennedy Krieger Baltimore, Maryland, United States, 21287 Contact: Kathryn Wagner, MD, PhD Collapse <<
NCT00887562	MELAS Syndrome	Phase 2	Completed	-	United States, New York ... more >> Columbia University Medical Center New York, New York, United States, 10032 Collapse <<
NCT03603288	Duchenne Muscular Dystrophy	Phase 3	Recruiting	January 2022	United States, Minnesota ... more >> Gillette Children's Specialty Healthcare Recruiting Saint Paul, Minnesota, United States, 55101 Contact: Randel Richardson, MD Belgium University Hospital Leuven Recruiting Leuven, Belgium, 3000 Contact: Gunnar Buyse, MD Principal Investigator: Gunnar Buyse, MD CHR Citadelle Recruiting Liège, Belgium, 4000 Principal Investigator: Laurent Servais, MD Italy Fondazione IRCCS Eugenio Medea Recruiting Bosisio Parini, Italy, 23842 Contact: Maria Grazia Nadia D'Angelo, MD Principal Investigator: Maria Grazia Nadia D'Angelo, MD Switzerland Center for neuromuscular disorders, Universitäts-Kinderspital beider Basel (UKBB) Recruiting Basel, Switzerland, 4301 Principal Investigator: Andrea Klein, MD United Kingdom Robert Jones and Agnes Hunt Orthopaedic Hospital Recruiting Oswestry, United Kingdom, SY10 7AG Contact: Tracey Willis, MD Principal Investigator: Tracey Willis, MD Collapse <<
NCT01303406	-	-	Completed	-	-

艾地苯醌 Catalog No. CSN11185

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