生物活性

• 描述Histamine is an organic nitrogenous compound involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. Histamine acts via H1 and H2 receptors to produce vasodilation and increased vascular permeability; elevated levels of histamine are found in inflamed tissue^[3]. Bilateral EP (experimental periodontitis) was induced for 2 weeks and histamine treatment (0.1 mg/kg subcutaneously) was started 5 days before the end of the experimental period in male rats. Histamine treatment partially reversed the methacholine-induced salivation reduction produced by EP while preventing SMG (submandibular gland) histological damage. Furthermore, histamine completely prevented enhanced EP-induced apoptosis. Histamine is able to reduce periodontitis-induced damage to SMG and bone structure^[4]. Histamines play an important role as a neurotransmitter in the central nervous system and participate in several physiological functions, such as the regulation of body temperature, food intake, circadian rhythm and analgesia. Histamines facilitate memory performance in mice^[5]. In HL-60 cells, histamine and 2-methylhistamine increased cytosolic Ca2+ concentration ([Ca2+]i) in a clemastine-sensitive manner. Histamine and 2-methylhistamine act as H1-receptor agonists in HL-60 cells^[6].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT01567319	Sensitization to Allergens	Phase 1	Completed	-	Spain ... more >> Hospital de Manises Manises, Valencia, Spain Hospital Universitario Infanta Cristina Badajoz, Spain Hospital Universitario Reina Sofía Córdoba, Spain Hospital Universitario de Guadalajara Guadalajara, Spain Complejo Hospitalario de Jaén Jaén, Spain Hospital General Universitario Gregorio Marañón Madrid, Spain Hospital Clínico Universitario Lozano Blesa Zaragoza, Spain Collapse <<
  NCT02474836	Hypersensitivity	Phase 2	Completed	-	Spain ... more >> Hospital de Vinalopó Elche, Alicante, Spain Alergoclínica Virgen de Loreto Córdoba, Andalucía, Spain Hospital General de Asturias Oviedo, Asturias, Spain Al-lergo centre Barcelona, Cataluña, Spain Hospital Universitario de Gran Canaria Dr. Negrín Las Palmas de Gran Canaria, Spain Clínica de asma y alergia Madrid, Spain Hospital Nuestra Señora De Candelaria Santa Cruz de Tenerife, Spain Hospital Arnau de Vilanova Valencia, Spain Hospital Clínico de Valencia Valencia, Spain Collapse <<
  NCT03192488	Exercise Intolerance at Altitu... more >>de Collapse <<	Phase 4	Recruiting	May 31, 2018	United States, Indiana ... more >> Indiana University Recruiting Bloomington, Indiana, United States, 47401 Contact: Robert Chapman, PhD    812-856-2452    rfchapma@indiana.edu Collapse <<

• 更多
• 参考文献

• [1] Liu X, Jones BL, et al. Population pharmacokinetic/pharmacodynamic modeling of histamine response measured by histamine iontophoresis laser Doppler. J Pharmacokinet Pharmacodyn. 2016 Aug;43(4):385-93.

  [2] Maintz L, Novak N. Histamine and histamine intolerance. Am J Clin Nutr. 2007 May;85(5):1185-96.

  [3] Greaves MW, Sabroe RA. Histamine: the quintessential mediator. J Dermatol. 1996 Nov;23(11):735-40

  [4] Prestifilippo JP, Carabajal E, Croci M, Fernández-Solari J, Rivera ES, Elverdin JC, Medina VA. Histamine modulates salivary secretion and diminishes the progression of periodontal disease in rat experimental periodontitis. Inflamm Res. 2012 May;61(5):455-64

  [5] Masuoka T, Nishiga M, Chen Z, Kamei C. [Participation of endogenous brain histamine on learning and memory]. Nihon Shinkei Seishin Yakurigaku Zasshi. 2006 Aug;26(4):141-8. Japanese

  [6] Hagelüken A, Grünbaum L, Klinker JF, Nürnberg B, Harhammer R, Schultz G, Leschke C, Schunack W, Seifert R. Histamine receptor-dependent and/or -independent activation of guanine nucleotide-binding proteins by histamine and 2-substituted histamine derivatives in human leukemia (HL-60) and human erythroleukemia (HEL) cells. Biochem Pharmacol. 1995 Mar 30;49(7):901-914

• 更多

• Collapse