|2-(2-氨基乙氧基)-5-氯-N-(2-氯-4-硝基苯基)苯甲酰胺盐酸盐|CsnPharm

CAS No.: 1420290-99-8

Synonyms: HJC0152 (hydrochloride);HJC0152 HCl;HJC-0152

HJC0152 inhibits STAT3 promoter activity in MDA-MB-231 cells in a dose-dependent manner.

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400-920-2911

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400-920-2911

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描述HJC0152 inhibits STAT3 promoter activity in MDA-MB-231 cells in a dose-dependent manner. It has a comparable potency in downregulating STAT3 protein production and phosphorylation at the Tyr-705 site. HJC0152 induces cleaved caspase-3 and downregulated cyclin D1 in MDA-MB-231 cells, inhibits cell cycle progression and promotes apoptosis. HJC0152 treatment efficiently suppresses HNSCC cell proliferation, arrests the cell cycle at the G0/G1 phase, induces apoptosis, and reduced cell invasion in both SCC25 and CAL27 cell lines. Moreover, HJC0152 inhibits nuclear translocation of phosphorylated STAT3 at Tyr705 and decreases VHL/β-catenin signaling activity via regulation of microRNA-21.

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技术信息

CAS号	1420290-99-8	储存条件	粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C15H14Cl3N3O4	运输	蓝冰
分子量	406.65	别名	HJC0152 (hydrochloride);HJC0152 HCl;HJC-0152

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