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CAS No.: 478-01-3

川陈皮素 Catalog No. CSN19425

Synonyms: Hexamethoxyflavone;NSC 76751;NSC 618903

Nobiletin, a citrus flavonoid extracted from the peel of citrus nobilis lour., has anti-inflammatory and anti-tumor activities.

规格	价格	促销价格	库存	数量

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技术信息

生物活性

描述Nobiletin (NOB), a polymethoxyflavone, has a few pharmacological activities, including anti-inflammation and anti-cancer effects. Nobiletin, up to 100 μM without cytotoxicity, significantly decreased motility, migration and invasion as well as enzymatic activities, protein levels and mRNA expressions of matrix metalloproteinase (MMP)-2 and MMP-9 in U2OS and HOS cells^[3]. NOB significantly improves metabolic fitness in naturally aged mice fed with a regular diet (RD). Furthermore, NOB enhances healthy aging in mice fed with a high-fat diet (HF)^[4]. Nobiletin plays a modulatory role in adipocytes via induction of browning in 3T3-L1 white adipocytes and activation of HIB1B brown adipocytes combined with amelioration of stress in adipocytes^[5]. Nobiletin improved cognitive deficits and the pathological features of AD, such as Aβ pathology, hyperphosphorylation of tau, and oxidative stress, in animal models of AD. In addition, nobiletin improved motor and cognitive deficits in PD animal models^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4851 mL
- 12.4256 mL
- 24.8512 mL
- 5 mM
- 0.4970 mL
- 2.4851 mL
- 4.9702 mL
- 10 mM
- 0.2485 mL
- 1.2426 mL
- 2.4851 mL

技术信息

CAS号

478-01-3

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H22O8

运输

蓝冰

分子量

402.39

别名

Hexamethoxyflavone;NSC 76751;NSC 618903;NOB;川陈皮素

溶解度

DMSO	41.25 mg/mL (102.5 mM)
Water	insoluble

动物实验配方

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