|2-((3-三氟甲基)苯基)氨基)苯甲酸|CsnPharm

CAS No.: 530-78-9

2-(3-Trifluoromethylanilino)benzoic Acid/氟芬那酸 Catalog No. CSN12744

Synonyms: Flufenamic Acid;CI-440;FFA

Flufenamic Acid is a COX inhibitor and prevents formation of prostaglandins, binds to and reduce the activity of prostaglandin F synthase and activate TRPC6, it is a NSAID drug.

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生物活性

描述Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), and also modulates ion channels, blocking chloride channels and L-type Ca2+ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid inhibits a wide spectrum of TRP channels, including: C3, C7, M2, M3, M4, M5, M7, M8, V1, V3, and V4 but activates at least two TRP channels (C6 and A1)^[3]. Flufenamic acid (FFA) has previously been demonstrated to be a potent activator of AMP-activated protein kinase (AMPK), which is a negative regulator of NF-κB signaling. In a mouse closed loop model of EL infection, FFA treatment (20mg/kg) significantly abrogated EL-induced intestinal fluid secretion and barrier disruption. In addition, FFA suppressed NF-κB nuclear translocation and expression of proinflammatory mediators and promoted AMPK phosphorylation in the EL-infected mouse intestine. Furthermore, FFA promoted tight junction assembly and prevented interferon gamma (IFN-γ)-induced barrier disruption in an AMPK-dependent manner^[4]. FFA inhibited cAMP-dependent Cl- secretion in T84 cell monolayers with IC50 of ∼8 μM. FFA inhibited Ca2+-dependent Cl- secretion with IC50 of ∼10 μM. FFA inhibited activities of Ca2+-activated Cl- channels and KCa3.1, a Ca2+-activated basolateral K+ channels, but had no effect on activities of Na+-K+-Cl- cotransporters and Na+-K+ ATPases^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03238612	Influenza A	Phase 2	Recruiting	October 31, 2020	Hong Kong ... more >> Ivan Hung Recruiting Hong Kong, Hong Kong Contact: Ivan FN Hung, MD FRCP 852 22554049 ivanfn@gmail.com Sub-Investigator: Kelvin To, MD FRCPath Sub-Investigator: KY Yuen, MD FRCPath Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.5558 mL
- 17.7790 mL
- 35.5581 mL
- 5 mM
- 0.7112 mL
- 3.5558 mL
- 7.1116 mL
- 10 mM
- 0.3556 mL
- 1.7779 mL
- 3.5558 mL

技术信息

CAS号

530-78-9

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C14H10F3NO2

运输

蓝冰

分子量

281.23

别名

Flufenamic Acid;CI-440;FFA;Fluphenamic Acid;NSC 82699;NSC 219007;CN-27554;INF-1837;氟芬那酸

溶解度

DMSO	140.0 mg/mL (497.8 mM)
Water	insoluble

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2-(3-Trifluoromethylanilino)benzoic Acid/氟芬那酸 Catalog No. CSN12744

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