|2-(4-羟基-3-甲氧基苯基)乙酸|CsnPharm

CAS No.: 306-08-1

高香草酸 Catalog No. CSN10217

Synonyms: Vanilacetic acid;Homovanillic Acid;高香草酸

Homovanillic Acid is a dopamine metabolite occurring in human biofluids, also barks of Ilex rotunda Thunb.

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技术信息

生物活性

描述Homovanillic Acid (HVA) is a metabolite of dopamine, reflecting central dopamine metabolism, primarily situated in the striatum^[3]. Moreover, reduced CSF (cerebrospinal fluid) HVA in LBD (Lewy body disorder) is supported by the finding that HVA is also reduced in the brains and CSF of PD (Parkinson disease) patients^[4].The metoclopramide induced increase of striatal HVA content was dose-dependent^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00106353	Adenocarcinoma ... more >> Neoplasms Collapse <<	Phase 1 Phase 2	Completed	-	-
NCT03180762	Healthy	Phase 1	Terminated(Trial stopped A SAE... more >> has occured. As a measure of precaution, the trial has been stopped.) Collapse <<	-	Belgium ... more >> Clinical Pharmacology Unit Merksem, Belgium, 2170 Collapse <<
NCT00659984	Neuroblastoma	Phase 2	Completed	-	United States, California ... more >> Childrens Hospital Los Angeles Los Angeles, California, United States, 90027-0700 Lucile Packard Children's Hospital at Stanford University Medical Center Palo Alto, California, United States, 94304 UCSF Helen Diller Family Comprehensive Cancer Center San Francisco, California, United States, 94115 United States, Illinois University of Chicago Comer Children's Hospital Chicago, Illinois, United States, 60637 United States, Michigan C.S. Mott Children's Hospital at University of Michigan Medical Center Ann Arbor, Michigan, United States, 48109-0286 United States, Ohio Cincinnati Children's Hospital Medical Center Cincinnati, Ohio, United States, 45229-3039 United States, Pennsylvania Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104-4318 United States, Texas Texas Children's Hospital Houston, Texas, United States, 77030 Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.4893 mL
- 27.4464 mL
- 54.8928 mL
- 5 mM
- 1.0979 mL
- 5.4893 mL
- 10.9786 mL
- 10 mM
- 0.5489 mL
- 2.7446 mL
- 5.4893 mL

技术信息

CAS号

306-08-1

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C9H10O4

运输

蓝冰

分子量

182.17

别名

Vanilacetic acid;Homovanillic Acid;高香草酸

溶解度

DMSO	98.0 mg/mL (537.9 mM)
Water	8.0 mg/mL (43.9 mM) warming

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00106353	Adenocarcinoma ... more >> Neoplasms Collapse <<	Phase 1 Phase 2	Completed	-	-
NCT03180762	Healthy	Phase 1	Terminated(Trial stopped A SAE... more >> has occured. As a measure of precaution, the trial has been stopped.) Collapse <<	-	Belgium ... more >> Clinical Pharmacology Unit Merksem, Belgium, 2170 Collapse <<
NCT00659984	Neuroblastoma	Phase 2	Completed	-	United States, California ... more >> Childrens Hospital Los Angeles Los Angeles, California, United States, 90027-0700 Lucile Packard Children's Hospital at Stanford University Medical Center Palo Alto, California, United States, 94304 UCSF Helen Diller Family Comprehensive Cancer Center San Francisco, California, United States, 94115 United States, Illinois University of Chicago Comer Children's Hospital Chicago, Illinois, United States, 60637 United States, Michigan C.S. Mott Children's Hospital at University of Michigan Medical Center Ann Arbor, Michigan, United States, 48109-0286 United States, Ohio Cincinnati Children's Hospital Medical Center Cincinnati, Ohio, United States, 45229-3039 United States, Pennsylvania Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104-4318 United States, Texas Texas Children's Hospital Houston, Texas, United States, 77030 Collapse <<
NCT00698009	-	-	Terminated(Slow accrual.)	-	-
NCT02852213	AADC Deficiency	Phase 1	Recruiting	June 2021	United States, California ... more >> University of California San Francisco, Benioff Children's Hospital Recruiting San Francisco, California, United States, 94143 Contact: Jill A Imamura-Ching, RN, BSN 415-476-3446 Jill.Imamura-Ching@ucsf.edu Contact: Waldy E San Sebastian, PhD Waldy.SanSebastian@ucsf.edu Principal Investigator: Nalin Gupta, MD Principal Investigator: Krystof Bankiewicz, MD Collapse <<
NCT00082758	-	-	Completed	-	-
NCT00106353	-	-	Completed	-	-
NCT00698009	Neuroblastoma	Phase 2	Terminated(Slow accrual.)	-	United States, Texas ... more >> UT MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse <<
NCT00659984	-	-	Completed	-	-
NCT00082758	Neuroblastoma	Phase 2	Completed	-	-
NCT01075373	-	-	Unknown	November 2010	Taiwan ... more >> National Taiwan University Hospital Taipei, Taiwan, 10002 Collapse <<
NCT01608178	-	-	Completed	-	United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse <<
NCT03764215	Huntington Disease	Phase 1	Recruiting	May 31, 2020	United States, District of Col... more >>umbia Georgetown University Medical Center Recruiting Washington, District of Columbia, United States, 20007 Contact: Hope Heller 202-687-1366 hope.heller@gunet.georgetown.edu Contact: Robin Kuprewicz, MA rk1028@georgetown.edu Collapse <<
NCT01990755	Anorexia Nervosa ... more >> Bulimia Nervosa Collapse <<	Not Applicable	Completed	-	Italy ... more >> Villa Garda Garda, Veneto, Italy, 37016 Collapse <<
NCT02954978	Parkinson Disease ... more >> Parkinsons Disease With Dementia Collapse <<	Phase 2	Active, not recruiting	July 2020	United States, District of Col... more >>umbia MedStar Georgetown University Hospital Washington, District of Columbia, United States, 20007 Collapse <<
NCT02518789	Myoclonus	Phase 4	Unknown	September 2016	-

高香草酸 Catalog No. CSN10217

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