|5-羟基吲哚乙酸|CsnPharm

CAS No.: 54-16-0

5-羟基吲哚-3-乙酸 Catalog No. CSN23462

Synonyms: 5-hydroxy Indole-3-acetic Acid;5-HIAA;5-Hydroxyindoleacetic Acid

5-Hydroxyindole-3-acetic acid (5-HIAA), the major metabolite of serotonin, is a histamine H1 receptor antagonist and can be used to treat allergies.

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技术信息

生物活性

描述5-Hydroxyindole-3-acetic acid (5-HIAA) is a catabolic end product of serotonin pathway. Urinary 5-hydroxyindole-3-acetic acid (5-HIAA) is a marker for diagnosis of patients with carcinoid tumors^[1]. Plasma 5-HIAA concentrations are high in subjects with MetS(metabolic syndrome), suggesting the potential importance of serotonin in the development of cardiovascular disease in MetS^[2]. And urinary 5-hydroxyindole-3-acetic acid (5-HIAA) is the markers currently used in the diagnosis, prognosis, and follow-up of patients with neuroendocrine tumors (NETs) ^[3].
参考文献

[1] Zhang Y, Li L, Gao Y, Wang X, Sun L, Ji W, Ozaki Y. Nitrosonaphthol reaction-assisted SERS assay for selective determination of 5-hydroxyindole-3-acetic acid in human urine. Anal Chim Acta. 2020 Oct 16;1134:34-40
[2] Fukui M, Tanaka M, Toda H, Asano M, Yamazaki M, Hasegawa G, Imai S, Nakamura N. High plasma 5-hydroxyindole-3-acetic acid concentrations in subjects with metabolic syndrome. Diabetes Care. 2012 Jan;35(1):163-7
[3] Bajetta E, Ferrari L, Martinetti A, Celio L, Procopio G, Artale S, Zilembo N, Di Bartolomeo M, Seregni E, Bombardieri E. Chromogranin A, neuron specific enolase, carcinoembryonic antigen, and hydroxyindole acetic acid evaluation in patients with neuroendocrine tumors. Cancer. 1999 Sep 1;86(5):858-65

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.2307 mL
- 26.1534 mL
- 52.3067 mL
- 5 mM
- 1.0461 mL
- 5.2307 mL
- 10.4613 mL
- 10 mM
- 0.5231 mL
- 2.6153 mL
- 5.2307 mL

技术信息

CAS号

54-16-0

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C10H9NO3

运输

蓝冰

分子量

191.18

别名

5-hydroxy Indole-3-acetic Acid;5-HIAA;5-Hydroxyindoleacetic Acid;5-hydroxy IAA;NSC 90432;Hydroxyindoleacetic acid;5-羟基吲哚-3-乙酸

溶解度

Ethanol

50.0 mg/mL (261.5 mM) warming

动物实验配方

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