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CAS No.: 50-18-0

环磷酰胺 Catalog No. CSN10722

Synonyms: CTX;环磷酰胺

Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.

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技术信息

生物活性

描述Cyclofosphamide is a potent immunosuppressive agent and the most commonly used drug in blood and marrow transplantation. Cyclophosphamide's unique metabolism and inactivation by aldehyde dehydrogenase is responsible for its distinct cytotoxic properties^[3]. High-dose chemotherapy and continuous daily oral regimens are associated with significant toxicity profiles, but i.v. pulsed regimens have lowered the rates of adverse effects in rheumatological studies^[4]. In haploidentical hematopoietic stem cell transplants, post-transplant cyclophosphamide together with standard prophylaxis reduces the incidence of GVHD (graft-versus-host disease) to acceptable rates without the need for T cell depletion^[5]. Moreover, using in vitro rodent embryo culture has demonstrated that Cyclofosphamide must be bioactivated to be teratogenic^[6]. High-dose cyclophosphamide (200 mg/kg) can as a conditioning regimen for allogeneic bone marrow transplantation. High-dose cyclophosphamide is maximally immunosuppressive, but not myeloablative. Early hematopoietic stem cells are spared the cytotoxicity of cyclophosphamide because of their high levels of aldehyde dehydrogenase, an enzyme that confers resistance to the drug^[7].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.8302 mL
- 19.1508 mL
- 38.3016 mL
- 5 mM
- 0.7660 mL
- 3.8302 mL
- 7.6603 mL
- 10 mM
- 0.3830 mL
- 1.9151 mL
- 3.8302 mL

技术信息

CAS号

50-18-0

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C7H15Cl2N2O2P

运输

蓝冰

分子量

261.09

别名

CTX;环磷酰胺

溶解度

DMSO	36.0 mg/mL (137.9 mM)
Water	30.0 mg/mL (114.9 mM) warming

动物实验配方

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