生物活性

• 描述Taurine, is an organic acid which is not utilized in protein synthesis, but rather is found free or in simple peptides. Taurine has many fundamental biological roles such as conjugation of bile acids, antioxidation, osmoregulation, membrane stabilization, and modulation of calcium signaling.Taurine (5, 10, and 20 mmol/L) promoted Ca2+ uptake in a concentration-dependent manner, as well as concentration dependently reducing the homocysteine (0.5 mmol/L)-induced inhibition of mitochondrial Ca2+ uptake^[3].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT03335488	Urea Cycle Disorder	Phase 4	Recruiting	March 31, 2020	United States, New York ... more >> Mount Sinai School of Medicine Recruiting New York, New York, United States, 10029 Contact: Dr. George Diaz, M.D., PhD.    212-241-0858    George.Diaz@mssm.edu    Contact: Luca Fierro    212 659 1477    luca.fierro@mssm.edu    Principal Investigator: Dr. George Diaz, M.D., PhD.          United States, Ohio University Hospitals Case Medical Center Recruiting Cleveland, Ohio, United States, 44106-6005 Contact: Dr. Jirair Bedoyan, MD    216-844-7124    Jirair.Bedoyan@UHhospitals.org    Contact: Audrey Lynn    216 844 7124    audrey.lynn@UHhospitals.org    United States, Pennsylvania Children's Hospital of Pittsburgh of UPMC Recruiting Pittsburgh, Pennsylvania, United States, 15224 Contact: Dr. Gerard Vockley, MD, PhD    412-692-7530    Jennifer.baker@chp.edu    Contact: Jennifer Baker    412-692-7530    Jennifer.baker@chp.edu    Principal Investigator: Dr. Gerard Vockley, MD, PhD          United States, Utah University of Utah Recruiting Salt Lake City, Utah, United States, 84132 Contact: Dr. Nicola Longo, M.D., PhD.    801-587-3605    Nicola.Longo@hsc.utah.edu    Contact: Carrie Bailey    801 587 3605    Carrie.Bailey@hsc.utah.edu    Principal Investigator: Dr. Nicola Longo, M.D., PhD.          Belgium Cliniques Universitaires Saint-Luc Recruiting Brussels, Belgium, 1200 Contact: Prof. Etienne Sokal, MD    32 2 764 13 87    etienne.sokal@uclouvain.be    Contact: Julia Versavau    32 2 764 19 33    julia.versavau@uclouvain.be    Principal Investigator: Prof. Etienne Sokal, MD          Spain Hospital Materno-Infantil (HRU Carlos Haya) Recruiting Málaga, Andalucia, Spain, 29006 Contact: Dr. Javier Blasco-Alonso, MD    34 951 29 21 91    javierblascoalonso@yahoo.es    Contact: Almudena Frias    34 951 29 21 91       Principal Investigator: Dr. Javier Blasco-Alonso          Hospital Clinico Universitario de Santiago Recruiting Santiago de Compostela, Galicia, Spain, 15706 Contact: Dr. Maria Luz Couce-Pico, MD    34 981 950 162    maria.luz.couce.pico@sergas.es    Contact: Maria Teresa Oreiro-Garcia    34 981 955 627    maria.teresa.oreiro.garcia@sergas.es    Principal Investigator: Dr. Maria Luz Couce-Pico, MD          Hospital Universitario de Cruces Recruiting Barakaldo, Vizcaya, Spain, 48903 Contact: Dr. Luis Jose Aldamiz-Echevar Azuara, MD    34 94 600 6327    LUISJOSE.ALDAMIZ-ECHEVARAZUARA@osakidetza.net    Contact: Fernando Olatz    34 94 600 6327    fernando.andradelodeiro@osakidetza.eus    Principal Investigator: Dr. Luis Jose Aldamiz-Echevar Azuara, MD          Switzerland Universitätsspital, Inselspital Bern Recruiting Bern, Switzerland, 3010 Contact: Matthias Gautchshi,, MD    41 (0)31 632 01 47    Matthias.Gautschi@insel.ch    Contact: Alexandra Nuoffer    +41 (0)31 632 51 37    alexandra.nuoffer@insel.ch    Principal Investigator: Dr. Matthias Gautchshi, MD          University Children's Hospital Recruiting Zurich, Switzerland, 75, 8032 Contact: Prof Johannes Häberle, MD    41- 44-266-7111    johannes.haeberle@kispi.uzh.ch    Contact: Ms. Doris Anzengruber    41- 44-266-7722    Doris.Anzengruber@kispi.uzh.ch    Principal Investigator: Prof Johannes Häberle, MD Collapse <<
  NCT01526655	Endometrial Cancer	Not Applicable	Unknown	August 2016	Sweden ... more >> Department of Obstetrics and Gynecology, Ryhov Central Hospital Not yet recruiting Jönköping, Jönköpings län, Sweden, 551 85 Contact: Laila Falknäs, MD    +4636321000    Laila.Falknas@lj.se    Contact: Johan Skoglund, MD    +4636321000    Johan.Skoglund@lj.se    Principal Investigator: Laila Falknäs, MD          Sub-Investigator: Johan Skoglund, MD          Department of Obstetrics and Gynecology, University Hospital Recruiting Linköping, Östergötland, Sweden, 58185 Contact: Preben Kjölhede, MD, PhD    +46101030000 ext 3187    Preben.Kjolhede@regionostergotland.se    Contact: Evelyn Lundin, MD    +46101030000    Evelyn.Lundin@regionostergotland.se    Principal Investigator: Preben Kjölhede, MD, PhD          Sub-Investigator: Evelyn Lundin, MD          Sub-Investigator: Shefqet Halili, MD          Sub-Investigator: Peter Lukas, MD          Sub-Investigator: Gulnara Kassymova, MD          Sub-Investigator: Ninnie Borendal Wodlin, MD, PhD Collapse <<
  NCT02340403	Neuropathy Pa... more >>inful Collapse <<	Not Applicable	Unknown	December 2016	France ... more >> CHU de Clermont-Ferrand Recruiting Clermont-Ferrand, France, 63003 Contact: Patrick LACARIN    04 73 75 11 95    placarin@chu-clermontferrand.fr    Principal Investigator: Denis PEZET Collapse <<

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• 参考文献

• [1] Huxtable RJ. Taurine in the central nervous system and the mammalian actions of taurine. Prog Neurobiol. 1989;32(6):471-533.

  [2] Chesney RW. Taurine: its biological role and clinical implications. Adv Pediatr. 1985;32:1-42.

  [3] Chaudhry S, Tandon B, Gupta A, Gupta S. Taurine: A potential mediator for periodontal therapy. Indian J Dent Res. 2018 Nov-Dec;29(6):808-811. doi: 10.4103/ijdr.IJDR_123_17. PMID: 30589012.