生物活性

• 描述Bronopol (2-bromo-2-nitropropane-1, 3-diol) is an antimicrobial compound widely used as a preservative, primarily in cosmetic formulations^[2]. Bronopol and bronidox completely eradicated P. aeruginosa and achieved an ∼5 log10 reduction in the S. aureus population. Bronopol and bronidox kill bacteria regardless of growth state, a property that endows them with broad-spectrum antibiofilm activity^[3]. Bronopol was identified as effective biocide and corrosion inhibitor which controls the both chemical and biocorrosion of MS in CWS (cooling tower water system)^[4]. Patterns of growth inhibition of Escherichia coli in the presence of 2-bromo-2-nitropropane-1,3-diol (bronopol) indicate a period of biocide-induced bacteriostasis followed by growth at an inhibited rate^[5].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT01797562	Allergic Contact Dermatitis	Phase 4	Unknown	December 2015	United States, California ... more >> Rady Children's Hospital Recruiting San Diego, California, United States, 92123 Contact: Ann Funk, RN    858-576-1700 ext 4295       Principal Investigator: Lawrence Eichenfield, MD          United States, Colorado Anschutz Health and Wellness Center, University of Colorado Recruiting Aurora, Colorado, United States, 80045 Contact: Teresa Derian, RN    303-724-9155       Principal Investigator: Cory Dunnick, MD          United States, Kentucky Dermatology Specialists Recruiting Louisville, Kentucky, United States, 40202 Contact: Maureen Beyel, RN    502-582-7546       Principal Investigator: Joseph Fowler, MD          United States, Oregon Oregon Health & Science University Recruiting Portland, Oregon, United States, 97239 Contact: Kristin Morton    503-494-6442       Principal Investigator: Patricia Norris, MD Collapse <<
  NCT01518348	Contact Dermatitis	Phase 3	Withdrawn(Study has been updat... more >>ed with new protocol number) Collapse <<	December 2013	United States, Colorado ... more >> Anschutz Health and Wellness Center, University of Colorado Aurora, Colorado, United States, 80045 United States, Kentucky Dermatology Specialists Louisville, Kentucky, United States, 40202 Collapse <<
  NCT00640614	Contact Dermatitis	Phase 3	Completed	-	United States, Arkansas ... more >> River City Dermatology Little Rock, Arkansas, United States, 72205 United States, Kansas American Dermatology Associates Shawnee, Kansas, United States, 66216 United States, Kentucky Dermatology Specialists PSC Louisville, Kentucky, United States, 40202-1864 United States, New York Winthrop University Hospital Mineola, New York, United States, 11501 Denmark Odense University Hospital Odense C, Denmark, DK-5000 Collapse <<

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• 参考文献

• [1] Chai SS, Qin ML, et al. Analysis of bronopol (2-bromo-2-nitropropan-1, 3-diol) residues in rice (Oryza sativa L.) by SPE using Bond Elut Plexa and liquid chromatography-tandem mass spectrometry. Anal Bioanal Chem. 2017 Nov 21.

  [2] Peters MS, Connolly SM, Schroeter AL. Bronopol allergic contact dermatitis. Contact Dermatitis. 1983;9(5):397–401

  [3] Peters MS, Connolly SM, Schroeter AL. Bronopol allergic contact dermatitis. Contact Dermatitis. 1983;9(5):397–401

  [4] Narenkumar J, Ramesh N, Rajasekar A. Control of corrosive bacterial community by bronopol in industrial water system. 3 Biotech. 2018;8(1):55

  [5] Shepherd JA, Waigh RD, Gilbert P. Antibacterial action of 2-bromo-2-nitropropane-1,3-diol (bronopol). Antimicrob Agents Chemother. 1988;32(11):1693–1698

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