|3-(2-氨基乙基)-2-甲基-1H-吲哚-5-醇|CsnPharm

CAS No.: 78263-90-8

2-Methyl-5-HT Catalog No. CSN27304

Synonyms: 2-Methyl-5-hydroxytryptamine;2-Methylserotonin;2-Me-5-HT

2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT is shown to display anti-depressive-like effects.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT is shown to display anti-depressive-like effects. Male Sprague Dawley rats were fed either a standard diet (11% fat) or a high-fat diet (32.5% fat) for seven days then treated with either fluoxetine (10mg/kg, ip), ondansetron (1mg/kg, ip), 2-methyl-5-HT (3mg/kg, ip), fluoxetine+ondansetron or, 2-methyl-5-HT+ondansetron prior to the Forced Swim Test. In the standard diet group, treatment with the 5HT3 receptor agonist, 2-methyl-5-HT, served to significantly decrease time of immobility as compared to controls thus showing anti-depressive-like effects. Reverse the anti-depressive-like effect of the 5HT3 receptor agonist, 2-methyl-5-HT and 3) provide protection against the depressive-like effects induced by the Forced Swim Test as rats fed a high-fat diet displayed the lowest amounts of immobility^[2]. The 5-HT(3) agonist, 2-methyl 5-HT, (10 microM) increased the frequency of CMMCs (colonic migrating motor complexes)^[3]. Afferent discharge evoked by 5-HT was significantly attenuated by co-injection with the selective 5-HT(3) receptor antagonist tropisetron (10(-3)M). Afferent discharge was also evoked by the selective 5-HT(3) receptor agonist 2-methyl-5-HT^[4].
参考文献

[1] Sumaya IC, et al. Differential effects of a short-term high-fat diet in an animal model of depression in rats treated with the 5-HT3 receptor antagonist, ondansetron, the 5-HT3 receptor agonist, 2-methyl-5-HT, and the SSRI, fluoxetine. Pharmacol Biochem Behav. 2016 May;144:78-84.
[2] Sumaya IC, Bailey D, Catlett SL. Differential effects of a short-term high-fat diet in an animal model of depression in rats treated with the 5-HT3 receptor antagonist, ondansetron, the 5-HT3 receptor agonist, 2-methyl-5-HT, and the SSRI, fluoxetine. Pharmacol Biochem Behav. 2016 May;144:78-84
[3] Fida R, Bywater RA, Lyster DJ, Taylor GS. Chronotropic action of 5-hydroxytryptamine (5-HT) on colonic migrating motor complexes (CMMCs) in the isolated mouse colon. J Auton Nerv Syst. 2000 Apr 12;80(1-2):52-63
[4] Sung D, Dong X, Ernberg M, Kumar U, Cairns BE. Serotonin (5-HT) excites rat masticatory muscle afferent fibers through activation of peripheral 5-HT3 receptors. Pain. 2008 Jan;134(1-2):41-50

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.2565 mL
- 26.2824 mL
- 52.5647 mL
- 5 mM
- 1.0513 mL
- 5.2565 mL
- 10.5129 mL
- 10 mM
- 0.5256 mL
- 2.6282 mL
- 5.2565 mL

技术信息

CAS号

78263-90-8

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C11H14N2O

运输

蓝冰

分子量

190.24

别名

2-Methyl-5-hydroxytryptamine;2-Methylserotonin;2-Me-5-HT

溶解度

DMSO	120.0 mg/mL (630.8 mM) warming

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

2-Methyl-5-HT Catalog No. CSN27304

靶点选择性

请登录您的专属账户

确认信息