CAS No.: 1452-77-3
吡啶酰胺 Catalog No. CSN11806
Synonyms: 2-Pyridinecarboxamide;Picolinoylamide;2-Carbamoylpyridine
Picolinamide is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.
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靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT03033485 Melanoma Not Applicable Not yet recruiting December 2018 China, Shaanxi ... more >> Xijing Hospital Nuclear Medicine Department Xi'an, Shaanxi, China, 710032 Collapse << - 参考文献
- [1] Campbell PI, al-Mahrouq HA, et al. Specific inhibition of rat renal Na+/phosphate cotransport by picolinamide. J Pharmacol Exp Ther. 1989 Oct;251(1):188-92.
- [2] Orpin CG, Knight M, Evans WC. The bacterial oxidation of picolinamide, a photolytic product of Diquat. Biochem J. 1972 May;127(5):819-31.
- [3] Uchigata Y, Yamamoto H, Kawamura A, Okamoto H. Protection by superoxide dismutase, catalase, and poly(ADP-ribose) synthetase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis. J Biol Chem. 1982;257(11):6084-6088.
- [4] Campbell PI, al-Mahrouq HA, Abraham MI, Kempson SA. Specific inhibition of rat renal Na+/phosphate cotransport by picolinamide. J Pharmacol Exp Ther. 1989;251(1):188-192.
- [5] Yamagami T, Miwa A, Takasawa S, Yamamoto H, Okamoto H. Induction of rat pancreatic B-cell tumors by the combined administration of streptozotocin or alloxan and poly(adenosine diphosphate ribose) synthetase inhibitors. Cancer Res. 1985;45(4):1845-1849.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1452-77-3 | 储存条件 |
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| 分子式 | C6H6N2O | 运输 | 蓝冰 | |||||
| 分子量 | 122.12 | 别名 | 2-Pyridinecarboxamide;Picolinoylamide;2-Carbamoylpyridine;2-Picolinamide;吡啶酰胺 | |||||
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动物实验配方 |
