|2-吡啶甲酸|CsnPharm

CAS No.: 98-98-6

2-吡啶甲酸 Catalog No. CSN25183

Synonyms: NV-02;NVTL-0001;2-吡啶甲酸

PCL016 is a pyridine carboxylate metabolite of tryptophan and acts as an anti-infective and immunomodulator. It acts by binding with the zinc associated with zinc finger proteins to alter their structure and inhibit function.

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400-920-2911

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技术信息

生物活性

描述Picolinic acid (PCL 016; PA) is a natural toxic pyridine derivative. Microorganisms can degrade and utilize PA for growth^[1]. In contrast to kynurenine and 3-hydroxyanthranilic acid, exposure of T cells with picolinic acid did not affect cell viability, whereas proliferation and metabolic activity were suppressed in a dose-dependent manner. Picolinic acid mediates a unique immunosuppressive program in T cells, mainly inhibiting cell cycle and metabolic activity, while leaving other effector functions intact^[2]. PIC (Picolinic acid) significantly decreased the electroconvulsive threshold and, after intracerebroventricular injection, but not subcutaneous, produced convulsions. Of the studied convulsants, only the activity of pilocarpine hydrochloride was significantly enhanced by PIC^[3]. Furthermore, picolinic acid may affect NO2- production via both TNF-alpha-dependent and TNF-alpha-independent pathways^[4].
参考文献

[1] Qiu J, Zhao L, Xu S, Chen Q, Chen L, Liu B, Hong Q, Lu Z, He J. Identification and Characterization of a Novel pic Gene Cluster Responsible for Picolinic Acid Degradation in Alcaligenes faecalis JQ135. J Bacteriol. 2019 Jul 24;201(16):e00077-19
[2] Prodinger J, Loacker LJ, Schmidt RL, Ratzinger F, Greiner G, Witzeneder N, Hoermann G, Jutz S, Pickl WF, Steinberger P, Marculescu R, Schmetterer KG. The tryptophan metabolite picolinic acid suppresses proliferation and metabolic activity of CD4+ T cells and inhibits c-Myc activation. J Leukoc Biol. 2016 Apr;99(4):583-94
[3] Cioczek-Czuczwar A, Czuczwar P, Turski WA, Parada-Turska J. Influence of picolinic acid on seizure susceptibility in mice. Pharmacol Rep. 2017 Feb;69(1):77-80
[4] Melillo G, Cox GW, Radzioch D, Varesio L. Picolinic acid, a catabolite of L-tryptophan, is a costimulus for the induction of reactive nitrogen intermediate production in murine macrophages. J Immunol. 1993 May 1;150(9):4031-40

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 8.1229 mL
- 40.6143 mL
- 81.2286 mL
- 5 mM
- 1.6246 mL
- 8.1229 mL
- 16.2457 mL
- 10 mM
- 0.8123 mL
- 4.0614 mL
- 8.1229 mL

技术信息

CAS号	98-98-6	储存条件	粉末 Keep in dark place,Sealed in dry,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C6H5NO2	运输	蓝冰
分子量	123.11	别名	NV-02;NVTL-0001;2-吡啶甲酸

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