|3,4,5-三羟基苯甲酸|CsnPharm

CAS No.: 149-91-7

没食子酸 Catalog No. CSN12566

Synonyms: 没食子酸;3,4,5-Trihydroxybenzoic acid

Gallic acid is an organic acid that found in a variety of foods and herbs with effective antioxidant activity.

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技术信息

生物活性

描述Gallic acid (3,4,5-Trihydroxybenzoic acid) is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2)^[3]. Gallic acid and its derivatives not only exhibit excellent antioxidant, anticarcinogenic, antimutagenic, antimicrobial properties but also provide protection to the cells against oxidative stress. Gallic acid (3, 4, 5-trihydroxybenzoic acid), a low molecular triphenolic compound emerged as an efficient apoptosis inducing agent^[4]. Gallic acid (10 mg/kg/day) improves glucose tolerance and lipid metabolism in the obesity mice, thereby showing evidence of anti-hyperglycemic activity^[5]. Acute toxicity of gallic acid was determined in albino mice and 28-days sub-acute toxicity study was carried out in male and female albino mice at three dose levels, 100, 300 and 900 mg/kg/day, p.o. LD50 of gallic acid was found to be greater than 2000 mg/kg in mice. High dose of gallic acid (900 mg/kg/day) for 28 days did not produce any significant alteration in morphological and behavioral parameters. Histopathological finding also supports safety of gallic acid in mice^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03214276	Healthy	Not Applicable	Completed	-	-
NCT03485885	-	-	Completed	-	Germany ... more >> Nutritional CRO & Study site; BioTeSys GmbH Esslingen, Baden-Württemberg, Germany, 73728 Collapse <<
NCT02273323	Vascular Function	Not Applicable	Completed	-	United Kingdom ... more >> Dept Clinical Pharmacology/CRF, St Thomas Hospital London, United Kingdom, SE1 7EH Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.8782 mL
- 29.3911 mL
- 58.7822 mL
- 5 mM
- 1.1756 mL
- 5.8782 mL
- 11.7564 mL
- 10 mM
- 0.5878 mL
- 2.9391 mL
- 5.8782 mL

技术信息

CAS号

149-91-7

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C7H6O5

运输

蓝冰

分子量

170.12

别名

没食子酸;3,4,5-Trihydroxybenzoic acid

溶解度

DMSO	123.0 mg/mL (723.0 mM)
Water	insoluble

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT03214276	Healthy	Not Applicable	Completed	-	-
NCT03485885	-	-	Completed	-	Germany ... more >> Nutritional CRO & Study site; BioTeSys GmbH Esslingen, Baden-Württemberg, Germany, 73728 Collapse <<
NCT02273323	Vascular Function	Not Applicable	Completed	-	United Kingdom ... more >> Dept Clinical Pharmacology/CRF, St Thomas Hospital London, United Kingdom, SE1 7EH Collapse <<
NCT02532088	Prediabetes	Phase 2	Not yet recruiting	September 2019	Malaysia ... more >> Seberang Jaya Hospital Not yet recruiting Seberang Jaya, Penang, Malaysia, 13700 Contact: Irene Looi, MRCP, FRCP irenelooi@yahoo.com Sub-Investigator: Hock Aun Ang, MRCP, FRCP Sub-Investigator: Irene Looi, MBBS Collapse <<
NCT02328339	Vascular Function	Not Applicable	Completed	-	-
NCT02273323	-	-	Completed	-	-
NCT01775384	Exercise-induced Inflammation ... more >> Exercise-induced Oxidative Stress Exercise-induced Immune Dysfunction Collapse <<	Not Applicable	Completed	-	United States, North Carolina ... more >> ASU Human Performance Laboratory, North Carolina Research Campus Kannapolis, North Carolina, United States, 28081 Collapse <<
NCT02800967	Hypertension ... more >>Overweight Collapse <<	Not Applicable	Unknown	June 2017	Serbia ... more >> Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade Belgrade, Serbia, 11000 Collapse <<
NCT02532101	Uncontrolled Insulin-treated T... more >>ype 2 Diabetes Mellitus Collapse <<	Not Applicable	Terminated(Study was terminate... more >>d due to futility.) Collapse <<	-	Malaysia ... more >> Seberang Jaya Hospital Seberang Jaya, Penang, Malaysia, 13700 Collapse <<
NCT02227615	Absorption; Chemicals	Not Applicable	Unknown	December 2017	United States, Texas ... more >> Exercise & Sport Nutrition Laboratory (ESNL) in the Department of Health and Kinesiology at Texas A&M University College station, Texas, United States, 77845 Collapse <<
NCT02005939	Cardiovascular Risk Factors	Not Applicable	Completed	-	United Kingdom ... more >> Queen Margaret University Edinburgh, Scotland, United Kingdom, EH21 6UU Collapse <<

没食子酸 Catalog No. CSN12566

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