|3,4-二羟基苄胺氢溴酸盐|CsnPharm

CAS No.: 16290-26-9

3,4-Dihydroxybenzylamine HBr/3,4-二羟基苄胺氢溴酸盐 Catalog No. CSN27391

Synonyms: NSC 263475 hydrobromide

3,4-Dihydroxybenzylamine hydrobromide (NSC 263475 hydrobromide) is an improved dopamine analog cytotoxic and inhibits DNA polymerase activity in melanoma cells. 3,4-Dihydroxybenzylamine hydrobromide (NSC 263475 hydrobromide) displays growth inhibitory activity in melanoma cell lines with varying degrees of tyrosinase activity.

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描述3,4-Dihydroxybenzylamine hydrobromide (NSC 263475 hydrobromide) is an improved dopamine analog cytotoxic and inhibits DNA polymerase activity in melanoma cells. Inhibition of DNA polymerase by activated 3,4-DHBA was shown by dialysis and kinetic studies to involve an irreversible reaction which occurs at two inhibitor interaction sites as determined by a Hill plot analysis. Double-stranded DNA protected the enzyme from inhibition by 3,4-DHBA, suggesting that the inhibitory sites are at or near the template-initiator binding site^[4]. 3,4-Dihydroxybenzylamine hydrobromide (NSC 263475 hydrobromide) displays growth inhibitory activity in melanoma cell lines with varying degrees of tyrosinase activity^[5].3,4-Dihydroxybenzylamine (DHBA), a dopamine analog, was much less toxic than dopamine when tested against the B16 melanoma in vivo and in vitro. Daily doses of 1,000 mg DHBA/kg were better tolerated than doses of 400 mg dopamine/kg. When tested against the B16 melanoma in (C57BL/6 x DBA/2)F1 mice, DHBA had a significantly improved therapeutic effect as shown by a life-span increased 70% as compared to 48% with dopamine. DHBA shared the catecholamine property of selectively inhibiting thymidine incorporation as compared to leucine or uridine incorporation^[6].
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实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.5441 mL
- 22.7207 mL
- 45.4414 mL
- 5 mM
- 0.9088 mL
- 4.5441 mL
- 9.0883 mL
- 10 mM
- 0.4544 mL
- 2.2721 mL
- 4.5441 mL

技术信息

CAS号	16290-26-9	储存条件	粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C7H10BrNO2	运输	蓝冰
分子量	220.06	别名	NSC 263475 hydrobromide

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3,4-Dihydroxybenzylamine HBr/3,4-二羟基苄胺氢溴酸盐 Catalog No. CSN27391

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