HCT116 cells | - | Growth inhibition assay | 48 h | Growth inhibition of human HCT116 cells overexpressing PI3Kalpha H1047R mutant after 48 hrs by MTT assay, IC50=4.1 μM | 22212721 |
HeLa cells | - | Function assay | - | Inhibition of MRP1 transfected in human HeLa cells assessed as inhibition of [3H]LTC4 transport by rapid filtration assay, Ki=2.4 μM | 19725578 |
HT-29 cells | - | Function assay | - | Desensitization of GPR35 receptor in human HT-29 cells assessed as inhibition of zaprinast-induced dynamic mass redistribution after 10 mins, IC50=2.12 μM | 24900447 |
human 22Rv1 cells | - | Proliferation assay | 144 h | Antiproliferative activity against human 22Rv1 cells incubated up to 144 hrs by Coulter particle count and size analyzer, IC50=13.1 μM | 22789812 |
human H9 cells | - | Function assay | 3 days | Antiviral activity against HIV1 3B infected in human H9 cells assessed as inhibition of viral replication after 3 days by p24 antigen capture assay, EC50=35 μM | 8158164 |
human HL60 cells | 30 μM | Proliferation assay | 48 h | Antiproliferative activity against human HL60 cells at 30 uM after 48 hrs by MTS assay | 18258440 |
human SKBR3 cells | - | Function assay | 24 h | Displacement of GM-cy3B from Hsp90 in human SKBR3 cells after 24 hrs by fluorescence polarization assay, IC50=13.5 μM | 24548207 |
human U2OS cells | - | Function assay | 5 h | Agonist activity at GPR35 receptor in human U2OS cells coexpressing Gal4-VP16-TEV assessed as beta arrestin translocation after 5 hrs by beta lactamase reporter gene assay, EC50=14.7 μM | 24900447 |
mouse L929 cells | - | Function assay | 2 h | Inhibition of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality treated with drug after 2 hrs of TNFalpha treatment | 9287415 |
NCI-60 human tumor cell line | - | Cytotoxicity assay | - | In vitro cytotoxic potency against NCI-60 human tumor cell line, GI50=36 μM | 9632366 |