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CAS No.: 548-83-4

高良姜素 Catalog No. CSN12256

Synonyms: 高良姜素;Norizalpinin;3,5,7-Trihydroxyflavone

Galangin functions as an antagonist of the aryl hydrocarbon receptor and also inhibits CYP1A1 (IC50 = 1 μM). It belongs to flavonoids and can be extracted from the rhizome of Zingiber officinale Roscoe with anti-inflammatory properties.

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技术信息

生物活性

描述Galangin shows inhibition of CYP1A1 (cytochrome P450 1A1) activity. Galangin inhibited the catabolic breakdown of DMBA (7,12-dimethylbenz[a]anthracene), as measured by thin-layer chromatography, in a dose-dependent manner. Galangin also inhibited the formation of DMBA-DNA adducts, and prevented DMBA-induced inhibition of cell growth. Moreover, galangin is a potent inhibitor of DMBA metabolism and an agonist/antagonist of the AhR^[3]. Galangin treatment inhibited cell proliferation and induced autophagy (130 μ mol/l) and apoptosis (370 μ mol/l). The galangin-induced autophagy was attenuated by the inhibition of p53 in HepG2 cells, and overexpression of p53 in Hep3B cells restored the galangin-induced higher percentage of cells with vacuoles to normal level^[4]. Galangin prevents HCC through multiple anti-cancer mechanisms, anti-genotoxic activity against environmental and dietary carcinogens; anti-proliferative effects through reversal of the Warburg effect in HCC(Hepatocellular carcinoma); arrest of the cell cycle in the G0/G1 phase; induction of apoptosis via stimulation of reactive oxygen species (ROS), endoplasmic reticulum (ER) stress, and the mitochondrial-dependent apoptosis pathway; induction of autophagy; and inhibition of angiogenesis, metastasis, and multidrug resistance (MDR) ^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.7005 mL
- 18.5023 mL
- 37.0046 mL
- 5 mM
- 0.7401 mL
- 3.7005 mL
- 7.4009 mL
- 10 mM
- 0.3700 mL
- 1.8502 mL
- 3.7005 mL

技术信息

CAS号

548-83-4

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H10O5

运输

蓝冰

分子量

270.24

别名

高良姜素;Norizalpinin;3,5,7-Trihydroxyflavone

溶解度

DMSO	53.0 mg/mL (196.1 mM)
Water	Insoluble
Ethanol	30.0 mg/mL (111.0 mM)

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