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CAS No.: 85801-02-1

吲哚美辛法呢酯 Catalog No. CSN11203

Synonyms: Indometacin farnesil;E 0710;Infree

Indometacin farnesil is a prodrug of the non-steroidal anti-inflammatory drug indometacin.

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纯度 & 质量文件批次:

靶点选择性

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描述Indomethacin farnesil (IMF) is a novel prodrug of indomethacin and has antiinflammatory effects. In the air pouch carrageenin-induced inflammation, an oral dose of IMF exerted dose dependent inhibitory effects on the accumulation of inflammatory exudate fluid and the migration of leukocytes into the exudate. In spite of the inability of IMF to inhibit prostaglandin synthesis in a cell free cyclooxygenase system, IMF injected locally inhibited carrageenin paw edema, and the inhibitory effect was comparable to that of indomethacin itself^[3]. Moreover, indomethacin farnesil was effective for myalgia and also decreased the number of CD16(+) CD56(-) NK cells^[4].
参考文献

[1] Ono K, Hashimoto T, Satoh T. Eosinophilic pustular folliculitis clinically presenting as orofacial granuloma: successful treatment with indomethacin, but not ibuprofen. Acta Derm Venereol. 2015 Mar;95(3):361-2.
[2] Hakozaki M, Kikuchi S, et al. Pseudogout of the acromioclavicular joint: report of two cases and review of the literature. Mod Rheumatol. 2011 Aug;21(4):440-3.
[3] Kumakura S, Mishima M, Kobayashi S, Shirota H, Abe S, Yamada K, Tsurufuji S. Inhibitory effect of indomethacin farnesil, a novel antiinflammatory prodrug, on carrageenin-induced inflammation in rats. Agents Actions. 1990 Mar;29(3-4):286-91
[4] Fujita Y, Fujii T, Takeda N, Tanaka M, Mimori T. Successful treatment of primary Sjögren's syndrome with chronic natural killer lymphocytosis by high-dose prednisolone and indomethacin farnesil. Intern Med. 2007;46(5):251-4

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.7789 mL
- 8.8946 mL
- 17.7892 mL
- 5 mM
- 0.3558 mL
- 1.7789 mL
- 3.5578 mL
- 10 mM
- 0.1779 mL
- 0.8895 mL
- 1.7789 mL

技术信息

CAS号	85801-02-1		储存条件	粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C34H40ClNO4		运输	蓝冰
分子量	562.14		别名	Indometacin farnesil;E 0710;Infree;INF

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工作液计算器 ✕

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