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CAS No.: 21637-25-2

异槲皮苷 Catalog No. CSN24711

Synonyms: Isoquercitroside

Isoquercitrin (Isoquercitroside) is an effective antioxidant and an eosinophilic inflammation suppressor.

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400-920-2911

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实验方案

技术信息

生物活性

描述Isoquercitrin (Isoquercitroside) is an effective antioxidant and an eosinophilic inflammation suppressor. 10 μM of Isoquercitrin of the seven compounds (myricitrin, isoquercitrin, hypoletin-7-O-β-D-xylopyranoside, quercitrin, kaempferin, kaempferol, and amentoflavone) partially but significantly blunt the negative effect of H2O2 on RGC-5 cells, as the viability of cells in the presence of H2O2 is increased from approximately 63% to 83% and 90% at 10 and 50 μM, respectively. Indeed, 50 μM Isoquercitrin is more effective as a neuroprotectant than the same concentration of EGCG. Furthermore, isoquercitrin potently attenuated the lipid peroxidation of rat brain homogenates initiated by nitric oxide, with an IC(50) value of 1.04 μM^[3]. Isoquercitrin was effective in alleviating soleus muscle mass loss following denervation in a dose-dependent manner (the optimal protective effect at 20 mg/kg/d). Isoquercitrin may alleviate soleus muscle atrophy and mitophagy and reverse the slow-to-fast fiber type conversion following denervation via inhibition of oxidative stress and inflammatory response^[4]. Treatment with ISO (Isoquercitrin) largely rescues STZ(streptozotocin)-induced differentiation inhibition and enhances neurite outgrowth of Neuro2a (N2a) cells in vitro. Moreover, oral administration of ISO protects hippocampal neurons from STZ-induced neurotoxicity and significantly improves the cognitive and behavioural impairment in STZ-induced AD rats^[5]. Isoquercitrin is also effective eosinophilic inflammation suppressors, suggesting a potential for treating allergies^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.1534 mL
- 10.7671 mL
- 21.5343 mL
- 5 mM
- 0.4307 mL
- 2.1534 mL
- 4.3069 mL
- 10 mM
- 0.2153 mL
- 1.0767 mL
- 2.1534 mL

技术信息

CAS号

21637-25-2

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H20O12

运输

蓝冰

分子量

464.38

别名

Isoquercitroside

溶解度

DMSO	120.0 mg/mL (258.4 mM) warming

动物实验配方

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