CAS No.: 5041-67-8
3-(((2S,3R,4R,5S)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one Catalog No. CSN14309
Juglanin, a natural product isolated and purified from the herbs of Phymatopteris hastate with antioxidant activity, shows protective effects on fructose-induced hepatitis by inhibiting inflammation and apoptosis through TLR4 and JAK2/STAT3 signaling pathways in fructose-fed rats, and can lead to G2/M phase arrest, induce apoptosis as well as autophagy through the ROS/JNK signaling pathway in human breast cancer cells, it may be a promising candidate for development of anti-tumor drugs targeting breast cancer.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Sun ZL, Dong JL, Wu J. Juglanin induces apoptosis and autophagy in human breast cancer progression via ROS/JNK promotion. Biomed Pharmacother. 2017 Jan;85:303-312.
- [2] Zhou GY, Yi YX, et al. The protective effect of juglanin on fructose-induced hepatitis by inhibiting inflammation and apoptosis through TLR4 and JAK2/STAT3 signaling pathways in fructose-fed rats. Biomed Pharmacother. 2016 Jul;81:318-28.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 5041-67-8 | 储存条件 |
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| 分子式 | C20H18O10 | 运输 | 蓝冰 | |
| 分子量 | 418.35 | 别名 |
