|3-((4-氯苯基)氨基甲酰基)萘-2-基磷酸二氢盐|CsnPharm

CAS No.: 18228-17-6

3-((4-Chlorophenyl)carbamoyl)naphthalen-2-yl dihydrogen phosphate Catalog No. CSN22252

Synonyms: Naphthol AS-E phosphate

KG-501 is histochemical substrate of alkaline phosphatases and can inhibit CREB-CBP interaction.

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生物活性

描述KG-501 is a CREB inhibitor, with an IC50 of 6.89 μM^[1]. KG-501 disrupts phospho (Ser-133) CREB binding to KIX with a Ki of ~90 μM, using concentrations of CREB that are within the linear range of the binding assay. Treatment of HEK293T cells with KG-501 also blocks induction of endogenous CREB target genes (NR4A2, αCG, c-fos, and RGS2) by forskolin, indicating that KG-501 likely exerts a general effect on CREB activity^[2]. In addition, KG-501 and CREB knockdown significantly decreased the levels of phosphorylated Akt, leading to a reduced number of oocytes with Foxo3a nuclear export. KG-501 also inhibited bpV (HOpic)-stimulated primordial follicle activation^[3]. At 10 μM, KG-501 suppresses the expression of all of the IL-1β-induced CXC chemokine genes except CXCL8. For the protein level, KG-501 significantly suppresses IL-1β-induced CXCL5 protein secretion^[4]. BAA (Bulleyaconitine) treatment induced phosphorylation of CREB (rather than NF-κB) and prodynorphin expression in cultured primary microglia, and antiallodynia in neuropathy, which were totally inhibited by the CREB inhibitor KG-501^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.6475 mL
- 13.2375 mL
- 26.4749 mL
- 5 mM
- 0.5295 mL
- 2.6475 mL
- 5.2950 mL
- 10 mM
- 0.2647 mL
- 1.3237 mL
- 2.6475 mL

技术信息

CAS号

18228-17-6

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C17H13ClNO5P

运输

蓝冰

分子量

377.72

别名

Naphthol AS-E phosphate

溶解度

DMSO	20.0 mg/mL (52.9 mM)
Water	Insoluble
Ethanol	Insoluble

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3-((4-Chlorophenyl)carbamoyl)naphthalen-2-yl dihydrogen phosphate Catalog No. CSN22252

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