|3-(2,4-二羟基苯基)丙酸|CsnPharm

CAS No.: 5631-68-5

3-(2,4-Dihydroxyphenyl)propanoic acid Catalog No. CSN19310

Synonyms: 2;4-Dihydroxyhydrocinnamic acid;3-(2,4-Dihydroxyphenyl)propionic Acid

2,4-Dihydroxyhydrocinnamic Acid shows tyrosinase inhibition activity when mixed with l-ascorbic acid, it is a natural product isolated and purified from the herbs of Juniperus formosana.

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技术信息

生物活性

描述Syn-2,3-dihydroxy-3 - (3,4-dihydroxyphenyl) propionic acid (m-DGA) is a synthetic derivative of chemical poly [3 - (3,4-dihydroxyphenyl) glyceric acid] (p-DGA). Both p-DGA and m-DGA inhibited the growth and induced death of prostate cancer cells, caused G1 phase arrest of PCa cells by regulating the expression of cell cycle regulators. Moreover, m-DGA (50 and 100 µg/mL) decreased 22Rv1 cell growth by 12–34% and 43–61% after 24 and 48h of treatment^[3].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02553265	Dysautonomia, Familial ... more >> Baroreflex Failure Syndrome Collapse <<	Phase 2	Recruiting	June 2019	United States, New York ... more >> NYU Langone Medical Center, Dyautonomia Center, Suite 9Q Recruiting New York, New York, United States, 10016 Contact: Jose M Martinez, MA 212-263-7225 jose.martinez@nyumc.org Contact: Lucy Norcliffe-Kaufmann, PhD 212 263 7225 ext 37489 norcll01@nyumc.org NYU Medical Center Recruiting New York, New York, United States, 10016 Contact: Jose Martinez, MA 212-263-7225 jose.martinez@nyumc.org Principal Investigator: Horacio Kaufmann, MD Principal Investigator: Lucy J Norcliffe-Kaufmann, PhD Collapse <<

参考文献

[1] Chen X, Haniu A, et al. The evaluation of the synergistic effect of 3-(2,4-dihydroxyphenyl)propionic acid and l-ascorbic acid on tyrosinase inhibition. Z Naturforsch C. 2017 Mar 1;72(3-4):119-121.
[2] Dann O, Volz G. A new synthesis of psoralene [(author's transl)] . Arch Pharm (Weinheim). 1975 Feb;308(2):121-30. German.
[3] Shrotriya S, Gagan D, Ramasamy K, Raina K, Barbakadze V, Merlani M, Gogilashvili L, Amiranashvili L, Mulkijanyan K, Papadopoulos K, Agarwal C, Agarwal R. Poly[3-(3, 4-dihydroxyphenyl) glyceric acid] from Comfrey exerts anti-cancer efficacy against human prostate cancer via targeting androgen receptor, cell cycle arrest and apoptosis. Carcinogenesis. 2012 Aug;33(8):1572-80. doi: 10.1093/carcin/bgs202. Epub 2012 Jun 12. PMID: 22693258; PMCID: PMC3499058.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.4894 mL
- 27.4469 mL
- 54.8938 mL
- 5 mM
- 1.0979 mL
- 5.4894 mL
- 10.9788 mL
- 10 mM
- 0.5489 mL
- 2.7447 mL
- 5.4894 mL

技术信息

CAS号	5631-68-5	储存条件	粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C9H10O4	运输	蓝冰
分子量	182.17	别名	2;4-Dihydroxyhydrocinnamic acid;3-(2,4-Dihydroxyphenyl)propionic Acid;2,4-二羟基氢肉桂酸

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