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CAS No.: 1135-24-6

阿魏酸 Catalog No. CSN10477

Synonyms: Coniferic acid;阿魏酸

Ferulic Acid is a naturally occuring phenolic phytochemical found in plant cell walls with antioxidant effect.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Ferulic Acid, a kind of phenolic compound isolated from Tetragonia tetragonioides, has many biological activities. In vitro studies, ferulic acid has whitening effect on the B16F10 mouse melanoma cell line and anti-wrinkle activity on the CCD-986sk human dermal fibroblast cell line, while shows no cytotoxicity at concentrations up to 20 μM^[1]. Besides this, it was found that ferulic acid could effectively inhibit the epidermal growth factor receptor (EGFR) in human breast cancer cells, through down-regulating the Tyr 1068 autophosphorylation^[2]. In vivo studies, ferulic acid has the ability of ameliorating the diabetes-induced cognition lesions in rat via the regulation of protein tyrosine phosphatase 1B (PTP1B) and insulin signaling pathway^[3]. In addition, ferulic acid could contribute to the reversal of inflammatory response induced by chronic unpredictable mild stress (CUMS) in mice^[4].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03092076	Healthy	Phase 1	Completed	-	-
NCT01982734	Pharmacokinetics of New Curcum... more >>in Formulations Safety of New Curcumin Formulations Collapse <<	Early Phase 1	Completed	-	Germany ... more >> University of Hohenheim Stuttgart, Baden-Württemberg, Germany, 70599 Collapse <<
NCT02944084	Safety After Oral Intake ... more >> Pharmacokinetics After Oral Intake Collapse <<	Early Phase 1	Completed	-	Germany ... more >> University of Hohenheim Stuttgart, Baden-Württemberg, Germany, 70599 Collapse <<

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参考文献

[1] Park HJ, Cho JH, et al. Whitening and anti-wrinkle activities of ferulic acid isolated from Tetragonia tetragonioides in B16F10 melanoma and CCD-986sk fibroblast cells. J Nat Med. 2018;72(1):127-135.
[2] Sudhagar S, Sathya S, et al. Inhibition of epidermal growth factor receptor by ferulic acid and 4-vinylguaiacol in human breast cancer cells. Biotechnol Lett. 2018;40(2):257-262.
[3] Wang H, Sun X, et al. Ferulic acid attenuates diabetes-induced cognitive impairment in rats via regulation of PTP1B and insulin signaling pathway. Physiol Behav. 2017.
[4] Liu YM, Shen JD, et al. Ferulic acid inhibits neuro-inflammation in mice exposed to chronic unpredictable mild stress. Int Immunopharmacol. 2017.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.1499 mL
- 25.7493 mL
- 51.4986 mL
- 5 mM
- 1.0300 mL
- 5.1499 mL
- 10.2997 mL
- 10 mM
- 0.5150 mL
- 2.5749 mL
- 5.1499 mL

技术信息

CAS号

1135-24-6

储存条件

粉末: Keep in dark place,Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C10H10O4

运输

蓝冰

分子量

194.18

别名

Coniferic acid;阿魏酸

溶解度

DMSO	195.0 mg/mL (1004.2 mM)
Water	insoluble

动物实验配方

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NCT03092076	Healthy	Phase 1	Completed	-	-
NCT01982734	Pharmacokinetics of New Curcum... more >>in Formulations Safety of New Curcumin Formulations Collapse <<	Early Phase 1	Completed	-	Germany ... more >> University of Hohenheim Stuttgart, Baden-Württemberg, Germany, 70599 Collapse <<
NCT02944084	Safety After Oral Intake ... more >> Pharmacokinetics After Oral Intake Collapse <<	Early Phase 1	Completed	-	Germany ... more >> University of Hohenheim Stuttgart, Baden-Württemberg, Germany, 70599 Collapse <<
NCT01293175	Overweight	Not Applicable	Completed	-	Italy ... more >> Department of Food Science Portici, Italy, 80055 Collapse <<
NCT02150356	Glucose and Lipid Metabolism ... more >> Incretin Hormones Plasma Levels Inflammation, Oxidative Stress and Endothelial Function Collapse <<	Not Applicable	Completed	-	Italy ... more >> Dept. Clinical Medicine and Surgery, Federico II University Naples, Italy, 80131 Collapse <<
NCT02353234	Dietary Modification	Not Applicable	Completed	-	Italy ... more >> University of Parma - Department of Food Science Parma, Italy, 43125 Collapse <<
NCT03451760	Behavioral and Psychiatric Sym... more >>ptoms of Dementia Collapse <<	Phase 2	Not yet recruiting	December 2019	-
NCT00777543	Healthy Males	Not Applicable	Completed	-	Netherlands ... more >> University of Maastricht Maastricht, Netherlands, 6200 MD Collapse <<

阿魏酸 Catalog No. CSN10477

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