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CAS No.: 40246-10-4

黄豆黄苷 Catalog No. CSN11706

Synonyms: Glycitein 7-O-β-glucoside;Glycitein-7-β-O-glucoside;Glycitein-7-beta-O-glucoside

Glycitin, a natural isoflavone, could promote the proliferation of bone marrow stromal cells and osteoblasts and protect the loss of bone. It can be isolated and purified from legumes.

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实验方案

技术信息

生物活性

描述Glycitin, a natural isoflavone, could promote the proliferation of bone marrow stromal cells and osteoblasts and protect the loss of bone. It can be isolated and purified from legumes. Administration of glycitin increased cell proliferation and promoted osteoblast formation from BMSCs. Furthermore, glycitin activated the gene expression of Col I and ALP in BMSCs. Notably, glycitin suppressed protein expression of TGF-β and AKT in BMSCs^[3]. Co-treatment with TMF and glycitin synergistically promotes the proliferation and migration of both keratinocytes and dermal fibroblasts, with a 1:1 ratio of these compounds showing the greatest efficacy in our co-culture system^[4]. Glycitin significantly prevents bone loss in variectomized (ovx) rats at a dose of 50 mg/kg/d. At this dose glycitin also prevents ovx-induced uterine atrophy and increases in body weight gain, abdominal fat, serum total cholesterol and triglyceride, and urinary excretion of pyridinoline and deoxypyridinoline with statistical significance^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02026518	Irritable Bowel Disease	Phase 4	Completed	-	Iran, Islamic Republic of ... more >> Gastrointestinal Clinics of Tehran University of Medical Sciences Tehran, Iran, Islamic Republic of Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.2401 mL
- 11.2006 mL
- 22.4012 mL
- 5 mM
- 0.4480 mL
- 2.2401 mL
- 4.4802 mL
- 10 mM
- 0.2240 mL
- 1.1201 mL
- 2.2401 mL

技术信息

CAS号

40246-10-4

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C22H22O10

运输

蓝冰

分子量

446.40

别名

Glycitein 7-O-β-glucoside;Glycitein-7-β-O-glucoside;Glycitein-7-beta-O-glucoside;ZX-AFC000687;黄豆黄素;黄豆黄苷

溶解度

DMSO	185.0 mg/mL (414.4 mM)
Water	insoluble

动物实验配方

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