|3-羟基-4-甲氧基苯甲醛|CsnPharm

CAS No.: 621-59-0

异香草醛 Catalog No. CSN12840

Synonyms: 3-Hydroxy-4-methoxybenzaldehyde;异香兰素

Isovanicaline, a natural product isolated and purified from the barks of Pinus yunnanensis, is a selective inhibitor of aldehyde oxidase, is metabolized by aldehyde dehydrogenase into isovanillic acid ,and the LD50 (rat, ipr) is 1276 mg/kg.

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生物活性

描述Isovanicaline widely exist in many plants, such as Pycnocycla spinosa. P^[1] . In vitro studies, isovanicaline, combined with curcumin and harmine, could suppress the proliferation of head and neck squamous cells by inhibiting the signaling pathway of EGFR, ERK1/2, and AKT^[2] . In vivo studies, it was found that the extract of arum palaestinum, containing high level of isovanicaline, had the ability of inhibiting the cell proliferation of xenografted prostate tumors in mice, while without signs of toxicity for non-cancer tissue^[3] . Besides this, isovanicaline could contribute to the detention of onset of diarrhoea and the reduction of wet defecation induced by castor oil and MgSO4 in mice^[1] .
参考文献

[1] Sadraei H, Ghanadian M, et al. Antidiarrheal activities of isovanillin, iso-acetovanillon and Pycnocycla spinosa Decne ex.Boiss extract in mice. Res Pharm Sci. 2014;9(2):83-9.
[2] Vishwakarma V, New J, et al. Potent Antitumor Effects of a Combination of Three Nutraceutical Compounds. Sci Rep. 2018;8(1):12163.
[3] Cole C, Burgoyne T, et al. Arum Palaestinum with isovanillin, linolenic acid and β-sitosterol inhibits prostate cancer spheroids and reduces the growth rate of prostate tumors in mice. BMC Complement Altern Med. 2015.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 6.5725 mL
- 32.8623 mL
- 65.7246 mL
- 5 mM
- 1.3145 mL
- 6.5725 mL
- 13.1449 mL
- 10 mM
- 0.6572 mL
- 3.2862 mL
- 6.5725 mL

技术信息

CAS号	621-59-0	储存条件	粉末 Keep in dark place,Sealed in dry,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C8H8O3	运输	蓝冰
分子量	152.15	别名	3-Hydroxy-4-methoxybenzaldehyde;异香兰素

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