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CAS No.: 83-34-1

粪臭素 Catalog No. CSN25160

Synonyms: 3-Methylindole;3-Methyl-1H-indole;粪臭素

Skatole (3-Methylindole) is a mildly toxic white crystalline organic compound that occurs naturally in feces. It has a fairly broad bacteriostatic effect.

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技术信息

生物活性

描述Skatole is produced by intestinal bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38. Skatole induces both AhR-dependent activation pathways and the AhR-independent (aryl hydrocarbon receptors)　activation of p38, consequently regulating the amount of IEC (intestinal epithelial cell) death. Skatole dose-dependently caused IEC death and time-dependently induced IEC apoptosis^[1]. Highly fermentable dietary fiber does not affect skatole production by reducing the number of skatole-producing bacteria or stimulating butyrate production in the large intestine^[2]. Skatole is a pulmonary toxin that induces the expression of aryl hydrocarbon receptor (AhR) regulated genes, such as cytochrome P450 1A1 (CYP1A1), in human bronchial cells. Skatole could reduce TCDD-induced CYP1A1 (cytochrome P450 1A1) expression, suggesting that skatole is a partial AhR agonist. Skatole and its metabolites affect liver homeostasis by modulating the AhR pathway^[3].
参考文献

[1] Kurata K, Kawahara H, Nishimura K, Jisaka M, Yokota K, Shimizu H. Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38. Biochem Biophys Res Commun. 2019;510(4):649-655
[2] Li X, Jensen BB, Canibe N. The Mode of Action of Chicory Roots on Skatole Production in Entire Male Pigs Is neither via Reducing the Population of Skatole-Producing Bacteria nor via Increased Butyrate Production in the Hindgut. Appl Environ Microbiol. 2019;85(6):e02327-18.
[3] Rasmussen MK, Balaguer P, Ekstrand B, Daujat-Chavanieu M, Gerbal-Chaloin S. Skatole (3-Methylindole) Is a Partial Aryl Hydrocarbon Receptor Agonist and Induces CYP1A1/2 and CYP1B1 Expression in Primary Human Hepatocytes. PLoS One. 2016;11(5):e0154629.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 7.6234 mL
- 38.1172 mL
- 76.2343 mL
- 5 mM
- 1.5247 mL
- 7.6234 mL
- 15.2469 mL
- 10 mM
- 0.7623 mL
- 3.8117 mL
- 7.6234 mL

技术信息

CAS号

83-34-1

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C9H9N

运输

蓝冰

分子量

131.17

别名

3-Methylindole;3-Methyl-1H-indole;粪臭素

溶解度

DMSO	26.0 mg/mL (198.2 mM)

动物实验配方

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