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CAS No.: 5142-23-4
Synonyms: 3-甲基腺嘌呤;3-MA
3-Methyladenine is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM.
生物活性
靶点 | PIK3C3 IC50:25μM | PI3Kγ IC50:60μM |
实验方案
技术信息
CAS号 | 5142-23-4 | 储存条件 |
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分子式 | C6H7N5 | 运输 | 蓝冰 | |||||||||||||
分子量 | 149.15 | 别名 | 3-甲基腺嘌呤;3-MA | |||||||||||||
溶解度 |
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动物实验配方 |
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Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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1321N1 | 5mM | Cytotoxicity Assay | 24h | protects cell against PCN-induced toxicity | 23525265 |
95D | 3mM | Growth Inhibition Assay | 2h | reduces growth inhibitory effect of BDMC | 25716561 |
95D | 5mM | Apoptosis Assay | 2h | inhibits BDMC-induced apoptotic cell death | 25716561 |
A2780 | 5mM | Apoptosis Assay | 24h | converts FTY720 with CDDP into an additive effect towards killing ovarian cancer cells | 23592281 |
A2780cp | 1mM | Growth Inhibition Assay | 1h | increases cisplatin-induced cell death | 25322694 |
A2780cp | 2.5mM | Apoptosis Assay | 1h | enhances cisplatin-induced cell death | 24817946 |
A2780cp | 2.5mM | Apoptosis Assay | 1h | enhances cisplatin-induced cell death | 24817946 |
A549 | 3mM | Growth Inhibition Assay | 2h | reduces growth inhibitory effect of BDMC | 25716561 |
A549 | 5mM | Apoptosis Assay | 2h | inhibits BDMC-induced apoptotic cell death | 25716561 |
A549 | 5mM | Function Assay | 2h | suppresses SPC induced accumulation of LC3-II | 25285628 |
A549 | 5mM | Apoptosis Assay | 48h | decreases the percentage of cell death and expression levels of caspase-3, Beclin-1 and LC3-II | 24706303 |
A549 | 10mM | Apoptosis Assay | 48h | accelerates the reduction of cell viability induced by PTX | 24626722 |
A549 | 10mM | Function Assay | 4h | inhibits autophagy induced by irradiation | 24142735 |
A549 | 0.1mM | Function Assay | 24h | suppresses SU11274-induced cell death | 22466960 |
ACHN-5968 | 5mM | Apoptosis Assay | 3h | enhances paclitaxel-mediated apoptosis | 24305604 |
BGC-823 | 5mM | Function Assay | 2h | inhibits the rate of autophagic cells | 22322152 |
ECSCs | 10mM | Apoptosis Assay | 4h | decreases rapamycin-treated apoptosis | 24319109 |
GTL-16 | 5mM | Apoptosis Assay | 24h | reduces cell viability as compared to cells treated with MET inhibitors | 23313490 |
H1299 | 10mM | Function Assay | 4h | increases cisplatin-induced cell death | 24173208 |
H157 | 5mM | Function Assay | 2h | suppresses SPC induced accumulation of LC3-II | 25285628 |
H460 | 10mM | Function Assay | 4h | increases cisplatin-induced cell death | 24173208 |
HBx | 10mM | Apoptosis Assay | 48h | increases cell death | 22020078 |
HCT116 | 5mM | Apoptosis Assay | 24h | enhances the apoptosis induced by apigenin | 24626522 |
HCT116 | 5mM | Apoptosis Assay | 24h | enhances apigenin-induced cell death | 24626522 |
HeLa | 10mM | Function Assay | 2h | suppresses LC3 II expressison | 23864738 |
Hela | 5mM | Function Assay | 24h | inhibits starvation-induced autophagy | 23395679 |
HeLa | 10mM | Apoptosis Assay | 2h | decreases cell viability co-treatment with PEI | 23000135 |
HeLa | 5mM | Apoptosis Assay | 24h | induces caspase-dependent cell death | 22545128 |
HeLa | 2mM | Cytotoxicity Assay | 24h | inhibites the cytotoxicity of silibinin to HeLa cells. | 21875385 |
Hep3B | 2mM | Apoptosis Assay | 12h | inhibits AZD8055-induced cell death | 24297300 |
Hep3B | 5mM | Apoptosis Assay | 24h | attenuates TNF-α protection against serum starvation-mediated apoptosis | 24066693 |
HepG2 | 5mM | Function Assay | 4h | increases HL release | 24713587 |
HepG2 | 10mM | Function Assay | 24h | inhibits siTIGAR- and HBSS-induced autophagy | 23817040 |
HepG2 | 3mM | Apoptosis Assay | 5h | reduces cell apoptosis induced by QDs | 22836595 |
HepG2 | 5mM | Function Assay | 4h | increases cellular levels of HL | 24713587 |
HepG2 | 2mM | Apoptosis Assay | 1h | enhances radiation-induced cell death | 21453691 |
HepG2 E47 | 2.5mM | Function Assay | 48h | increases the toxicity of AA, BSO, and CCl4 | 24273738 |
HGC-27 | 10mM | Function Assay | 1h | inhibits the cell viability loss by RAD001 or MK-2206 | 24416349 |
HO8910 | 10mM | Apoptosis Assay | 12h | enhances B19-induced apoptosi | 23983610 |
HONE-1 | 5mM | Function Assay | 1h | represses 6r-mediated ROS production | 23892358 |
HT-29 | 1mM | Apoptosis Assay | 48h | enhances bortezomib-induced cell viability loss | 24842158 |
HT-29 | 1mM | Function Assay | 48/96h | inhibits AMPK induces autophagic cell death | 23508272 |
Huh7 | 2mM | Apoptosis Assay | 12h | inhibits AZD8055-induced cell death | 24297300 |
HUVECs | 3mM | Function Assay | 24h | blocks the protective effect of resveratrol by inhibiting autophagy | 23358928 |
HUVECs | 10mM | Function Assay | 0.5h | decreases the AGE-BSAinduced autophagy leve | 21468592 |
Jurkat | 10mM | Function Assay | 1h | decreases the expression of LC3-II and the formation of autophagosomes | 21864037 |
K562 | 10mM | Function Assay | 1h | decreases the expression of LC3-II and the formation of autophagosomes | 21864037 |
LoVo | 5mM | Apoptosis Assay | 48h | enhances DCA-induced apoptosis. | 24201812 |
Marc-145 | 5mM | Function Assay | 12/24/36h | reduces the PRRSV titers and the protein expression | 22119900 |
MCF7 | 5mM | Function Assay | 24h | increases CuO induced cell death | 23962629 |
MCF-7 | 10mM | Function Assay | 24h | inhibits the autophagy induced by chemotherapy drugs | 24315578 |
MCF-7 | 5mM | Function Assay | 24h | inhibits starvation-induced autophagy | 23395679 |
MCF-7 | 2mM | Function Assay | 24h | inhibits autophagy induced by TM | 24970676 |
MCF-7 | 2mM | Function Assay | 48h | promotes TM-induced cell death | 24970676 |
MCF-7 | 0.1mM | Apoptosis Assay | 6h | enhances sirtinol-induced apoptosis | 22751989 |
MCF-7 | 10mM | Function Assay | 48h | blocks autophagy induced by bortezomib | 21931937 |
MDA-MB 231 | 5mM | Apoptosis Assay | 0.5h | modulates Tocomin® induced apoptosis | 24830781 |
MDA-MB231 | 5mM | Function Assay | 1h | increases resveratrol-mediated caspase activation and cell death | 23088850 |
MDA-MB-231 | 2mM | Function Assay | 24h | inhibits autophagy induced by TM | 24970676 |
MDA-MB-231 | 2mM | Function Assay | 48h | promotes TM-induced cell death | 24970676 |
MDR | 10mM | Apoptosis Assay | 6h | strengthens the power of anticancer drugs | 25019701 |
MG-63 | 0.5/1mM | Function Assay | 48h | induces salinomycin-induced cell viability loss | 24358342 |
MG-63 | 0.5/1mM | Apoptosis Assay | 32h | enhances salinomycin-induced cell apoptosis | 24358342 |
MG-63 | 10mM | Apoptosis Assay | 12h | enhances DP-induced apoptosis | 24358301 |
Microglia | 5mM | Apoptosis Assay | 24h | decreases hypoxia-induced cell death | 24818601 |
Microglia | 5mM | Apoptosis Assay | 24h | decreases hypoxia-induced cell death | 24818601 |
Nara-H | 5mM | Growth Inhibition Assay | 48h | enhances temsirolimusmediated suppression of Nara-H cell proliferation | 21805033 |
NBL-W-S | 1mM | Growth Inhibition Assay | 6h | enhances GANT-61 toxicity | 25323222 |
NBL-W-S | 1mM | Apoptosis Assay | 6h | increases cell apoptosis induced by GANT-61 | 25323222 |
NTUB1 | 5mM | Apoptosis Assay | 1.5h | potentiates celecoxib-induced apoptosis | 24349176 |
OR6 | 10mM | Function Assay | 72h | suppresses HCV replication and formation of autophagosomes | 23395875 |
OV2008 | 5mM | Apoptosis Assay | 24h | converts FTY720 with CDDP into an additive effect towards killing ovarian cancer cells | 23592281 |
PaCa44 | 2.5mM | Apoptosis Assay | 1h | reduces genipin-mediated apoptosis | 23124112 |
PANC-1 | 1mM | Apoptosis Assay | 48h | enhances bortezomib-induced cell viability loss | 24842158 |
PC12 | 10mM | Function Assay | 24h | inhibits chymotrypsin-like proteasomal activity. | 23603979 |
PC12/TetOn | 0.1/1mM | Function Assay | 18h | leads to α-syn(WT) accumulation, toxicity, and oligomer formation | 21906659 |
PC-3 | 2mM | Apoptosis Assay | 2h | increases ORI-induced cell death | 22745580 |
pDCs | 10mM | Function Assay | 0.5h | reduces the induction of IFN-α by ssRNA40 | 22396599 |
RKO | 2mM | Function Assay | 1h | enhances cell death by geldanamycin | 24291777 |
RMPI8226 | 5mM | Function Assay | 1h | suppresses the level of autophagy under nutrient depletion | 21915620 |
Saos-2 | 10mM | Apoptosis Assay | 24h | intensifies the growth inhibition of the U2OS cells induced by Dox | 24639013 |
Saos-2 | 1mM | Apoptosis Assay | 96h | increases cell death induced by PCX | 23563171 |
SGC-7901 | 2mM | Apoptosis Assay | 1h | increases CA-4 induced apoptosis | 24321340 |
SH-SY5Y | 1mM | Function Assay | 24h | inhibits the autophagy induced by TOCP | 23743148 |
SH-SY5Y | 5mM | Apoptosis Assay | 1h | abolishes celastrol neuroprotective effect | 23619395 |
SH-SY5Y | 5mM | Cytotoxicity Assay | 24h | increases PCN toxicity | 23525265 |
SK-HEP-1 | 10mM | Apoptosis Assay | 1h | protects against autophagy and induces apoptosis in bufalin-treated cells | 22858649 |
SMMC-7721 | 2mM | Apoptosis Assay | 1h | increases CA-4 induced apoptosis | 24321340 |
SMMC-7721 | 5mM | Apoptosis Assay | 24h | attenuates TNF-α protection against serum starvation-mediated apoptosis | 24066693 |
T24 | 5mM | Apoptosis Assay | 1.5h | potentiates celecoxib-induced apoptosis | 24349176 |
T24 | 10mM | Function Assay | 1h | reduces the cleavage of LC3 after baicalin treatment | 23354080 |
T-47D | 10mM | Function Assay | 2h | inhibits autophagy process and increases rapamycin induced apoptosis | 23300026 |
U251 | 5mM | Apoptosis Assay | 24h | increases S1-induced cell death | 22579788 |
U251MG | 3mM | Function Assay | 1h | suppresses LC3-II protein expression | 23338618 |
U2OS | 10mM | Apoptosis Assay | 24h | intensifies the growth inhibition of the U2OS cells induced by Dox | 24639013 |
U2OS | 0.5/1mM | Function Assay | 48h | induces salinomycin-induced cell viability loss | 24358342 |
U2OS | 10mM | Growth Inhibition Assay | 24h | intensifies the growth inhibition induced by Dox | 24639013 |
U937 | 2mM | Function Assay | 12h | decreases the autophagy ratio | 22155150 |
UOK257 | 5mM | Apoptosis Assay | 3h | enhances paclitaxel-mediated apoptosis | 24305604 |
WiDr | 10mM | Function Assay | 1h | inhibits PCBL-induced LC3 II expression | 24190489 |
靶点 | Description | IC50 |
---|---|---|
PIK3C3 | IC50:25μM | |
PI3Kγ | IC50:60μM |
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