|3-甲基-7-氯-1,2,4-苯并噻二嗪1,1-二氧化物|CsnPharm

CAS No.: 364-98-7

二氮嗪 Catalog No. CSN12647

Synonyms: Sch-6783;SRG-95213;NSC 64198

Diazoxide is an ATP-sensitive potassium channel activator which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. and can be used to treat hyperinsulinism.

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400-920-2911

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描述Diazoxide (Sch-6783) is an ATP-sensitive potassium channel activator, has the potential for hyperinsulinism treatment. Diazoxide has powerful protective properties against cardiac ischemia. Diazoxide may have several potential effectors that may potentially contribute to cardioprotection, including KATP channels in the pancreas, smooth muscle, endothelium, neurons and the mitochondrial inner membrane. Diazoxide may also affect other ion channels and ATPases and may directly regulate mitochondrial energetics^[3]. Diazoxide is a neuroprotective agent against oxidative stress-induced damage and cellular dysfunction. Diazoxide effectively protects NSC-34 motoneurons from glutamatergic, oxidative and inflammatory damage. Moreover, diazoxide decreased neuronal death in organotypic hippocampal slice cultures after exicitotoxicity and preserved myelin sheath in organotypic cerebellar cultures exposed to pro-inflammatory demyelinating damage^[4]. Diazoxide attenuates postresuscitation brain injury, protects mitochondrial function, inhibits brain cell apoptosis, and activates the PKC pathway by opening mitoKATP channels^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.3352 mL
- 21.6760 mL
- 43.3520 mL
- 5 mM
- 0.8670 mL
- 4.3352 mL
- 8.6704 mL
- 10 mM
- 0.4335 mL
- 2.1676 mL
- 4.3352 mL

技术信息

CAS号

364-98-7

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C8H7ClN2O2S

运输

蓝冰

分子量

230.67

别名

Sch-6783;SRG-95213;NSC 64198;NSC 76130;Eudemine;Hyperstat;Proglycem;Hypertonalum;Proglicem;二氮嗪

溶解度

DMSO	165.0 mg/mL (715.3 mM) warming
Water	insoluble

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