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CAS No.: 6066-49-5

3-n-Butylphathlide;3-Butylphthalide/正丁基苯酞 Catalog No. CSN19391

Synonyms: 3-n-Butylphthalide;3-Butylphthalide;(±)-NBP

Butylphthalide, a natural product isolated and purified from the herbs of Ligusticum jeholense with antihypertensive effects, may slow the progression of hypertensive nephropathy by a variety of mechanisms, and is effective for improving cognitive and global functioning in patients with subcortical VCIND and exhibits good safety.

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生物活性

描述Butylphthalide (3-N-Butylphthalide, NBP), a family of compounds initially isolated from the seeds of Apium graveolens Linn., has shown significant neuroprotective effects^[3]. Butylphthalide may inhibit nerve cell apoptosis in rats with cerebral infarction to exert a protective effect, which may be associated with the JNK/p38 MAPK signaling pathway^[4]. Butylphthalide has neuroprotective effect on the mouse model of MCAO. It may upregulate the level of miR-21 to inhibit neuronal apoptosis and ROS production and improve the proliferation activity^[5]. Butylphthalide injection has a high clinical efficacy in treating hypertensive intracerebral hemorrhages^[6]. Butylphthalide combined with conventional treatment can decrease MMP-9 levels and increase VEGF levels^[7]. 3-N-butylphthalide (Butylphthalide) administration improved the neuronal morphology in the cerebral cortex and hippocampus of rats with chronic cerebral ischemia, increased choline acetyltransferase activity, and decreased malondialdehyde and amyloid beta levels, and greatly improved cognitive function^[8].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02594995	Cerebrovascular Occlusion ... more >> Collateral Blood Circulation Anterior Cerebral Circulation Infarction Collapse <<	Phase 4	Unknown	September 2016	China, Zhejiang ... more >> The second affiliated hospital of Zhejiang University Hangzhou, Zhejiang, China, 310000 Collapse <<
NCT01556854	-	-	Unknown	June 2014	China, Beijing ... more >> Tiantan hospital Recruiting Beijing, Beijing, China, 100050 Contact: Yilong Wang, Doctor 00861067098222 yilong528@Gmail.com Collapse <<
NCT03394950	Stroke, Ischemic	Phase 4	Recruiting	March 30, 2019	China ... more >> General Hospital of ShenYang Military Region Recruiting ShenYang, China Contact: Xin-Hong Wang, PhD 86-24-28897491 450341972@qq.com Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.2566 mL
- 26.2828 mL
- 52.5656 mL
- 5 mM
- 1.0513 mL
- 5.2566 mL
- 10.5131 mL
- 10 mM
- 0.5257 mL
- 2.6283 mL
- 5.2566 mL

技术信息

CAS号

6066-49-5

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C12H14O2

运输

蓝冰

分子量

190.24

别名

3-n-Butylphthalide;3-Butylphthalide;(±)-NBP;NBP;丁基苯酞;正丁基苯酞

溶解度

DMSO	54.0 mg/mL (283.9 mM)

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02594995	Cerebrovascular Occlusion ... more >> Collateral Blood Circulation Anterior Cerebral Circulation Infarction Collapse <<	Phase 4	Unknown	September 2016	China, Zhejiang ... more >> The second affiliated hospital of Zhejiang University Hangzhou, Zhejiang, China, 310000 Collapse <<
NCT01556854	-	-	Unknown	June 2014	China, Beijing ... more >> Tiantan hospital Recruiting Beijing, Beijing, China, 100050 Contact: Yilong Wang, Doctor 00861067098222 yilong528@Gmail.com Collapse <<
NCT03394950	Stroke, Ischemic	Phase 4	Recruiting	March 30, 2019	China ... more >> General Hospital of ShenYang Military Region Recruiting ShenYang, China Contact: Xin-Hong Wang, PhD 86-24-28897491 450341972@qq.com Collapse <<
NCT02711683	-	-	Recruiting	March 2018	China, Shaanxi ... more >> First Affiliated Hospital of Xi'an Jiaotong University Recruiting Xi'an, Shaanxi, China, 710061 Contact: Jin Wang 0086-13572208524 drwangjin@163.com Collapse <<
NCT02905565	AIS	Phase 2	Recruiting	November 2020	-
NCT02149875	-	-	Completed	-	-
NCT00724724	Stroke Transi... more >>ent Ischemic Attack Collapse <<	Phase 4	Unknown	August 2011	-
NCT02149875	Acute Cerebral Stroke Within 1... more >>2 Hours for the First Time Collapse <<	Phase 1 Phase 2	Completed	-	China ... more >> Shanghai Sixth People's Hospital Shanghai, China Collapse <<
NCT03539445	Acute Ischemic Stroke	Phase 3	Recruiting	September 30, 2019	China, Beijing ... more >> Beijing Tiantan Hospital Recruiting Beijing, Beijing, China, 100050 Contact: Zhongrong Miao, MD.,Ph.D Collapse <<
NCT01405248	Restenosis	Phase 3	Completed	-	China, Jiangsu ... more >> Department of Neurology ;Jinling Hospital Nanjing,, Jiangsu, China, 210002 Collapse <<
NCT02993367	Vascular Cognitive Impairment ... more >>no Dementia Collapse <<	Phase 2 Phase 3	Recruiting	July 2019	China, Hebei ... more >> Second Affiliated Hospital of Hebei medical university Recruiting Shijiazhuang, Hebei, China, 050000 Contact: zhu yifei, master +8613303046666 13831155688@163.com Contact: liang panpan, master +8617717711528 674691785@qq.com Collapse <<
NCT03413202	Acute Ischemic Stroke	Phase 4	Recruiting	July 2020	China, Jilin ... more >> First Hospital of Jilin University Recruiting Changchun, Jilin, China, 130000 Contact: Yi Yang, MD, PhD doctor_yangyi@163.com Collapse <<

3-n-Butylphathlide;3-Butylphthalide/正丁基苯酞 Catalog No. CSN19391

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