|乙酰基-ALPHA-乳香酸|CsnPharm

CAS No.: 89913-60-0

3-O-Acetyl-α-boswellic acid/乙酰基-ALPHA-乳香酸 Catalog No. CSN24765

Synonyms: α-Boswellic acid acetate;ABA;alpha-Acetylboswellic acid

3-O-Acetyl-α-boswellic acid (Aαba) is a pentacyclic triterpene extracted from the gum resin of genus Boswellia and has been shown to have analgesic, anti-arthritic, anti-inflammatory, and anti-cancer effects.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述3-O-Acetyl-α-boswellic acid (Aαba) is a pentacyclic triterpene extracted from the gum resin of genus Boswellia and has been shown to have analgesic, anti-arthritic, anti-inflammatory, and anti-cancer effects. A 2-day exposure of young human skin fibroblasts (passage 8) with 1 µM Aαba significantly increased cell survival and metabolic activity compared to non-treated cells. However, Aαba at the doses of 50 - 100 µM resulted in a dose-dependent inhibitory effect on MTT activity and reached almost 100% toxicity at 100 µM. In near-senescent cells (passage 51), Aαba at high concentration (75 and 100 µM) suppressed the MTT activity to a lesser extent compared with the young cells. In replicatively senescent cells (passage 58), treatment with 1 μM Aαba morphologically rejuvenated late passage cells. The exposure of early passage cells (passage 14) with 1 µM Aαba for 24 h resulted in downregulated the expressions of CCNH, CDKN1B, CDKN2A, E2F3, CCNE1, HDAC1, cyclin D1, CDKN1A, cyclin dependent kinase 7, and transforming growth factor beta 2, and upregulated CDKN2C and CDKN1A levels as compared to cells at late passage^[1]. Treatment of monocytes with AαBA (1 - 10µM) inhibited LPS-induced expression of TNF-α in a dose-dependent manner. In HEK293 cells transiently transfected with pNFκB-Luc vector and stimulated with TNF-α (100 ng/mL), a pretreatment with AαBA at 10 µM inhibited NF-κB activation by 40.9 ± 9.8%. AαBA at 10 µM also significantly abolished the nuclear localization of p65 in LPS-stimulated monocytes^[2].
参考文献

[1] Lewinska A, Sodagam L, Bloniarz D, Siems K, Wnuk M, Rattan SIS. Plant-Derived Molecules α-Boswellic Acid Acetate, Praeruptorin-A, and Salvianolic Acid-B Have Age-Related Differential Effects in Young and Senescent Human Fibroblasts In Vitro. Molecules. 2019 Dec 29;25(1):141. doi: 10.3390/molecules25010141. PMID: 31905790; PMCID: PMC6982785.
[2] Syrovets T, Büchele B, Krauss C, Laumonnier Y, Simmet T. Acetyl-boswellic acids inhibit lipopolysaccharide-mediated TNF-alpha induction in monocytes by direct interaction with IkappaB kinases. J Immunol. 2005 Jan 1;174(1):498-506. doi: 10.4049/jimmunol.174.1.498. PMID: 15611276.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0051 mL
- 10.0253 mL
- 20.0506 mL
- 5 mM
- 0.4010 mL
- 2.0051 mL
- 4.0101 mL
- 10 mM
- 0.2005 mL
- 1.0025 mL
- 2.0051 mL

技术信息

CAS号	89913-60-0	储存条件	粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C32H50O4	运输	蓝冰
分子量	498.74	别名	α-Boswellic acid acetate;ABA;alpha-Acetylboswellic acid;α-acetyl Boswellic Acid;3-O-acetyl-α-Boswellic Acid

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

3-O-Acetyl-α-boswellic acid/乙酰基-ALPHA-乳香酸 Catalog No. CSN24765

靶点选择性

请登录您的专属账户

确认信息