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CAS No.: 4339-72-4

3-O-Acetyloleanolic acid/齐墩果酸3-乙酸酯 Catalog No. CSN13311

Synonyms: Oleanolic Acid Acetate;3-Acetyloleanolic Acid;3-O-Acetyloleanolic acid

3-O-Acetyloleanolic Acid exhibits anti-angiogenic effects and induces apoptosis in HUVECs and HCT-116 cells, it is a natural product isolated and purified from the herbs of Phytolacca americana.

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400-920-2911

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生物活性

描述3-O-acetyloleanolic acid (3AOA), a pentacyclic triterpenoid compound isolated from seeds of Vigna sinensis K., has been reported to have potent anti-angiogenesis and anti-tumor activities. 3AOA inhibits VEGF-A-induced lymphangiogenesis and sentinel lymph node metastasis both in vitro and in vivo^[3]. 3-O-acetyloleanolic acid dose-dependently inhibited the viability of HCT-116 cells. 3-O-acetyloleanolic acid induces apoptosis in HCT-116 cells mediated by an extrinsic apoptosis signaling cascade via up-regulation of DR5^[4]. 3-O-acetyloleanolic acid exerts an apoptosis in cancer cell lines, is an inhibition of both atopic and allergic contact dermatitis in murine model, and a suppression of inflammatory bone loss in mice^[5]. 3AOA has an inhibitory effect on angiogenesis and lymphangiogenesis induced by angiopoietin-1 both in vitro and in vivo, and the inhibitory effect of 3AOA is probably due to suppression of angiopoietin-1/Tie-2 signaling in HUVEC (human umbilical vein endothelial cells) and HLMEC (human lymphatic microvascular endothelial cells) ^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0051 mL
- 10.0253 mL
- 20.0505 mL
- 5 mM
- 0.4010 mL
- 2.0051 mL
- 4.0101 mL
- 10 mM
- 0.2005 mL
- 1.0025 mL
- 2.0051 mL

技术信息

CAS号	4339-72-4	储存条件	粉末 Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C32H50O4	运输	蓝冰
分子量	498.74	别名	Oleanolic Acid Acetate;3-Acetyloleanolic Acid;3-O-Acetyloleanolic acid;齐墩果酸3-乙酸酯;齐墩果酸乙酸酯

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