|3-苄基-5-((2-硝基苯氧基)甲基)二氢呋喃-2(3H)-酮|CsnPharm

CAS No.: 890405-51-3

3BDO Catalog No. CSN23318

Synonyms: 3-benzyl-5-((2-nitrophenoxy) methyl)-dihydrofuran-2(3H)-one

3BDO is a new mTOR activator which can also inhibit autophagy.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述3BDO is a new mTOR activator which can also inhibit autophagy. It inhibited autophagy in human umbilical vein endothelial cells (HUVECs) and neuronal cells. 3BDO activated MTOR by targeting FKBP1A (FK506-binding protein 1A, 12 kDa). Activation of mTOR by 3BDO increased the phosphorylation of TIA1 (TIA1 cytotoxic granule-associated RNA binding protein/T-cell-restricted intracellular antigen-1)^[1]. In vivo experiments confirmed that 3BDO activated mTOR and decreased the protein level of ATG13 in the plaque endothelium of apoE(-/-) mice. Importantly, 3BDO did not affect the activity of mTOR and autophagy in macrophage cell line RAW246.7 and vascular smooth muscle cells of apoE(-/-) mice, but suppressed plaque endothelial cell death and restricted atherosclerosis development in the mice. 3BDO protected VECs by activating mTOR and thus stabilized atherosclerotic lesions in apoE(-/-) mice^[2]. 3BDO increased levels of insulin-degrading enzyme and neprilysin, suppressed autophagy via an mTOR pathway, lowered levels of Aβ, and prevented AD-like cognitive deficits in the AβPP/PS1 double transgenic mouse model^[3].
参考文献

[1] Ge D, Han L, Huang S, Peng N, Wang P, Jiang Z, Zhao J, Su L, Zhang S, Zhang Y, Kung H, Zhao B, Miao J. Identification of a novel MTOR activator and discovery of a competing endogenous RNA regulating autophagy in vascular endothelial cells. Autophagy. 2014 Jun;10(6):957-71
[2] Peng N, Meng N, Wang S, Zhao F, Zhao J, Su L, Zhang S, Zhang Y, Zhao B, Miao J. An activator of mTOR inhibits oxLDL-induced autophagy and apoptosis in vascular endothelial cells and restricts atherosclerosis in apolipoprotein E⁻/⁻ mice. Sci Rep. 2014 Jul 1;4:5519
[3] Wei L, Yang H, Xie Z, Yang S, Yang H, Zhao C, Wang P, Xu S, Miao J, Zhao B, Bi J. A butyrolactone derivative 3BDO alleviates memory deficits and reduces amyloid-β deposition in an AβPP/PS1 transgenic mouse model. J Alzheimers Dis. 2012;30(3):531-43

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.0550 mL
- 15.2750 mL
- 30.5501 mL
- 5 mM
- 0.6110 mL
- 3.0550 mL
- 6.1100 mL
- 10 mM
- 0.3055 mL
- 1.5275 mL
- 3.0550 mL

技术信息

CAS号

890405-51-3

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H17NO5

运输

蓝冰

分子量

327.33

别名

3-benzyl-5-((2-nitrophenoxy) methyl)-dihydrofuran-2(3H)-one

溶解度

DMSO	63.0 mg/mL (192.5 mM)
Water	Insoluble
Ethanol	48.0 mg/mL (146.6 mM)

动物实验配方

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3BDO Catalog No. CSN23318

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