|2,3,4,5-四-(4-吡啶)噻吩|CsnPharm

CAS No.: 64048-12-0

4,4',4'',4'''-(Thiophene-2,3,4,5-tetrayl)tetrapyridine Catalog No. CSN18697

Synonyms: NSC 75503

GANT 58 is a potent Gli antagonist that inhibits GLI1-induced transcription (IC50 = 5 μM).

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Glioma-associated oncogene homolog 1 (GLI1) is an amplified gene in human glioblastoma cells. It is a krupple like transcription factor, belonging to the zinc finger family. The basic function of GLI1 is normal neural development at various stages of human^[3].GANT58 (NSC75503) has been shown to inhibit transcriptional activation by GLI1 (as well as by the other GLI species). GANT58 has been shown to inhibit GLI transactivation^[4].GANT 58 (NSC 75503) is a potent GLI antagonist that inhibits GLI1-induced transcription with IC50 of 5 μM. Nude mice are treated with every second-day s.c. injections at a concentration of 50 mg/kg of cyclopamine, GANT61, GANT58, or solvent only (n=4-5 for each group). Although mice treated with these compounds showed no such signs of toxicity, this protocol is also introduced for the GANTs to be able to compare all compounds. All injections are done 2-3 cm away from the tumors. Suppression of tumor cell growth is observed for all compounds, during an 18-day treatment period. Treatment with cyclopamine or GANT58 results in the inhibition of additional xenograft growth and limited the increase in tumor size^[5].GANT-58 at 5μM significantly abolished oxytocin-induced mRNA and protein expression of HIF-1α, while the nuclear abundance of Gli1 was significantly reduced by atosiban at 10μM, but was increased by oxytocin at 0.1μM in human umbilical vein endothelial cells(HUVECs). GANT-58 at 5μM also significantly abolished oxytocin-enhanced angiogenic properties of HUVECs^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.5479 mL
- 12.7396 mL
- 25.4793 mL
- 5 mM
- 0.5096 mL
- 2.5479 mL
- 5.0959 mL
- 10 mM
- 0.2548 mL
- 1.2740 mL
- 2.5479 mL

技术信息

CAS号	64048-12-0	储存条件	粉末 Keep in dark place,Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C24H16N4S	运输	蓝冰
分子量	392.48	别名	NSC 75503

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

4,4',4'',4'''-(Thiophene-2,3,4,5-tetrayl)tetrapyridine Catalog No. CSN18697

靶点选择性

请登录您的专属账户

确认信息